Cbz-valylglycyl hydrazide | 33477-44-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Cbz-valylglycyl hydrazide
• CAS: 33477-44-0
• 化学式: C₁₅H₂₂N₄O₄
• 分子量: 322.364
• InChiKey: NCSPGPOUDJBIEG-ZDUSSCGKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.04
• 重原子数：
  23.0
• 可旋转键数：
  7.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  122.55
• 氢给体数：
  4.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  Cbz-valylglycyl hydrazide 、 乙酰丙酮 在 对甲苯磺酸 作用下， 以 甲醇 为溶剂， 反应 16.0h， 生成 1-(Cbz-valylglycyl)-3,5-dimethylpyrazole
  参考文献：
  名称：

  New System for Peptide Synthesis Using N-Acylpyrazoles

  摘要：

  New system of peptide synthesis was described. The extension of one amino acid unit on the peptide chain was constituted from only 2 reaction steps, the conversion from esters to the corresponding N-acylpyrazoles and the subsequent aminolysis with amino esters. This new system was distinctive from the conventional peptide synthesis, which was consisted of 3 steps of the deprotection, the activation and the condensation. Moreover, the key intermediate N-acylpyrazoles exhibited the excellent properties of high sensitivity and separability for the chiral column on HPLC using the UV detector.

  DOI：

  10.3987/com-99-s51
• 作为产物：
  描述：

  Cbz-Val-NH-NH2 在 对甲苯磺酸 、 一水合肼 、 三乙胺 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 18.66h， 生成 Cbz-valylglycyl hydrazide
  参考文献：
  名称：

  New System for Peptide Synthesis Using N-Acylpyrazoles

  摘要：

  New system of peptide synthesis was described. The extension of one amino acid unit on the peptide chain was constituted from only 2 reaction steps, the conversion from esters to the corresponding N-acylpyrazoles and the subsequent aminolysis with amino esters. This new system was distinctive from the conventional peptide synthesis, which was consisted of 3 steps of the deprotection, the activation and the condensation. Moreover, the key intermediate N-acylpyrazoles exhibited the excellent properties of high sensitivity and separability for the chiral column on HPLC using the UV detector.

  DOI：

  10.3987/com-99-s51