tert-butyl-dimethyl-(3-pyrazol-1-ylpropoxy)silane | 191734-36-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: tert-butyl-dimethyl-(3-pyrazol-1-ylpropoxy)silane
• 英文别名: 1-[3-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]propyl]-1H-pyrazole
• CAS: 191734-36-8
• 化学式: C₁₂H₂₄N₂OSi
• 分子量: 240.421
• InChiKey: UAXQCDVZVXABQK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  16.0
• 可旋转键数：
  5.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  27.05
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  tert-butyl-dimethyl-(3-pyrazol-1-ylpropoxy)silane 在 二硫化碳 、 溴 、 三正丁基氢锡 、 sodium hydride 、 sodium carbonate 、 碘甲烷 作用下， 生成 (2R,4S)-4-Benzoylsulfanyl-2-[1-(3-hydroxy-propyl)-1H-pyrazol-4-ylmethyl]-pyrrolidine-1-carboxylic acid allyl ester
  参考文献：
  名称：

  Studies on β-lactam antibiotics. Synthesis and antibacterial activity of novel 1β-methylcarbapenems related to FR21818: 5-membered ring analogs

  摘要：

  The synthesis and biological activity of the novel series of 1 beta-methylcarbapenems 1 are described. Most compounds displayed extremely potent antibacterial activity and high renal DHP-1 stability. The best compound in this series, FR21818 (1a) displayed excellent in vivo efficacy against an MRSA infection in mice. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00230-8
• 作为产物：
  描述：

  1H-吡唑-1-丙酸甲酯 在 lithium aluminium tetrahydride 作用下， 生成 tert-butyl-dimethyl-(3-pyrazol-1-ylpropoxy)silane
  参考文献：
  名称：

  Studies on β-lactam antibiotics. Synthesis and antibacterial activity of novel 1β-methylcarbapenems related to FR21818: 5-membered ring analogs

  摘要：

  The synthesis and biological activity of the novel series of 1 beta-methylcarbapenems 1 are described. Most compounds displayed extremely potent antibacterial activity and high renal DHP-1 stability. The best compound in this series, FR21818 (1a) displayed excellent in vivo efficacy against an MRSA infection in mice. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00230-8

文献信息

• [EN] SMALL MOLECULE MODULATORS OF IL-17<br/>[FR] MODULATEURS À PETITES MOLÉCULES D'IL-17
  申请人：LEO PHARMA AS

  公开号：WO2021255174A1

  公开（公告）日：2021-12-23

  The present invention relates to compounds according to formula I (I) and pharmaceutically acceptable salts, hydrates, or solvates thereof. The invention further relates to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases, e.g. dermal diseases, with said compounds, and to the use of said compounds in the manufacture of medicaments.

  本发明涉及公式I（I）的化合物及其药用盐、水合物或溶剂化合物。该发明还涉及所述化合物在治疗中的用途，包括含有所述化合物的药物组合物，用所述化合物治疗疾病的方法，例如皮肤疾病，并且涉及所述化合物用于制造药品。