2-acetamido-2-deoxy-3,4,6-tri-O-acetyl-β-D-galactopyranosyl-(1->4)-2,4,6-tri-O-benzyl-β-D-galactopyranosyl-(1->4)-1,2,3,6-tetra-O-benzyl-D-glucopyranose | 98044-44-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-acetamido-2-deoxy-3,4,6-tri-O-acetyl-β-D-galactopyranosyl-(1->4)-2,4,6-tri-O-benzyl-β-D-galactopyranosyl-(1->4)-1,2,3,6-tetra-O-benzyl-D-glucopyranose
• CAS: 98044-44-1
• 化学式: C₇₅H₈₃NO₁₉
• 分子量: 1302.48
• InChiKey: KRSSBKSWMSPJBL-UZRQPRQVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.85
• 重原子数：
  95.0
• 可旋转键数：
  32.0
• 环数：
  10.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  218.76
• 氢给体数：
  1.0
• 氢受体数：
  19.0

反应信息

• 作为反应物：
  描述：

  2-acetamido-2-deoxy-3,4,6-tri-O-acetyl-β-D-galactopyranosyl-(1->4)-2,4,6-tri-O-benzyl-β-D-galactopyranosyl-(1->4)-1,2,3,6-tetra-O-benzyl-D-glucopyranose 在 sodium methylate 、 20 % Pd(OH)2/C 、 氢气 作用下， 以 甲醇 为溶剂， 反应 13.0h， 以90%的产率得到2-acetamido-2-deoxy-β-D-galactopyranosyl-(1->4)-β-D-galactopyranosyl-(1->4)-D-glucopyranose
  参考文献：
  名称：

  Bishydrazide Glycoconjugates for Lectin Recognition and Capture of Bacterial Pathogens

  摘要：

  Bishydrazides are versatile linkers for attaching glycans to substrates for lectin binding and pathogen detection schemes. The alpha,omega-bishydrazides of carboxymethylated hexa(ethylene glycol) (4) can be conjugated at one end to unprotected oligosaccharides, then attached onto carrier proteins, tethered onto activated carboxyl-terminated surfaces, or functionalized with a photoactive cross-linking agent for lithographic patterning. Glycoconjugates of bishydrazide 4 can also be converted into dithiocarbamates (DTCs) by treatment with CS2 under mild conditions, for attachment onto gold substrates. The immobilized glycans serve as recognition elements for cell-surface lectins and enable the detection and capture of bacterial pathogens such as Pseudomonas aeruginosa by their adsorption onto micropatterned substrates. A detection limit of 10(3) cfu/mL is demonstrated, using a recently introduced method based on optical pattern recognition.

  DOI：

  10.1021/bc100288c
• 作为产物：
  描述：

  2-deoxy-3,4,6-tri-O-acetyl-2-trichloroacetamido-β-D-galactopyranosyl-(1->4)-2,4,6-tri-O-benzyl-β-D-galactopyranosyl-(1->4)-1,2,3,6-tetra-O-benzyl-D-glucopyranose 在 偶氮二异丁腈 、 三正丁基氢锡 作用下， 以 苯 为溶剂， 反应 1.0h， 以70%的产率得到2-acetamido-2-deoxy-3,4,6-tri-O-acetyl-β-D-galactopyranosyl-(1->4)-2,4,6-tri-O-benzyl-β-D-galactopyranosyl-(1->4)-1,2,3,6-tetra-O-benzyl-D-glucopyranose
  参考文献：
  名称：

  Bishydrazide Glycoconjugates for Lectin Recognition and Capture of Bacterial Pathogens

  摘要：

  Bishydrazides are versatile linkers for attaching glycans to substrates for lectin binding and pathogen detection schemes. The alpha,omega-bishydrazides of carboxymethylated hexa(ethylene glycol) (4) can be conjugated at one end to unprotected oligosaccharides, then attached onto carrier proteins, tethered onto activated carboxyl-terminated surfaces, or functionalized with a photoactive cross-linking agent for lithographic patterning. Glycoconjugates of bishydrazide 4 can also be converted into dithiocarbamates (DTCs) by treatment with CS2 under mild conditions, for attachment onto gold substrates. The immobilized glycans serve as recognition elements for cell-surface lectins and enable the detection and capture of bacterial pathogens such as Pseudomonas aeruginosa by their adsorption onto micropatterned substrates. A detection limit of 10(3) cfu/mL is demonstrated, using a recently introduced method based on optical pattern recognition.

  DOI：

  10.1021/bc100288c

文献信息

• A stereocontrolled total synthesis of a ganglio-ganglioside GM1b, IV3NeuAcαGgOse4Cer
  作者：Mamoru Sugimoto、Kazushige Fujikura、Shigeki Nunomura、Toshio Horisaki、Yukishige Ito、Tomoya Ogawa

  DOI：10.1016/s0040-4039(00)94561-1

  日期：1990.1

  A first total synthesis of ganglio ganglioside GM1b. α-D-NeupAc-(2→3)-β-D-Galp(1→3)-β-D-GalpNAc-(1→4)-β-D-Galp-(1→4)-β-D-Glcp-(1→1)-Cer, was achieved in a stereocontrolled manner.

  的第一全合成ganglio神经节苷脂GM1b。α-d-neu的p的Ac-（2→3）-β-d-Gal的p（1→3）-β-d-Gal的p NAc-（1→4）-β-d-Gal的p - （1→ 4）-β-d-GLC p - （1→1）-Cer，在一个立体控制的方式来实现。