14-Chloro-12-(4-methylphenyl)-10-oxa-1-azatetracyclo[9.7.1.03,8.015,19]nonadeca-3,5,7,11(19),12,14,16-heptaen-18-one | 1187578-39-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 14-Chloro-12-(4-methylphenyl)-10-oxa-1-azatetracyclo[9.7.1.03,8.015,19]nonadeca-3,5,7,11(19),12,14,16-heptaen-18-one
• 英文别名: 14-chloro-12-(4-methylphenyl)-10-oxa-1-azatetracyclo[9.7.1.03,8.015,19]nonadeca-3,5,7,11(19),12,14,16-heptaen-18-one
• CAS: 1187578-39-7
• 化学式: C₂₄H₁₈ClNO₂
• 分子量: 387.865
• InChiKey: WPGSOMVYMMEEDV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  28
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  14-Chloro-12-iodo-10-oxa-1-azatetracyclo[9.7.1.03,8.015,19]nonadeca-3,5,7,11,13,15(19),16-heptaen-18-one 、 4-甲苯硼酸 在 四(三苯基膦)钯 、 sodium carbonate 作用下， 以 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 0.28h， 以74%的产率得到14-Chloro-12-(4-methylphenyl)-10-oxa-1-azatetracyclo[9.7.1.03,8.015,19]nonadeca-3,5,7,11(19),12,14,16-heptaen-18-one
  参考文献：
  名称：

  Synthesis of novel benzoxazocino quinoliniums and quinolones under PTC conditions and their application in Suzuki cross coupling reaction for the construction of polynuclear heteroaromatics

  摘要：

  A general and highly efficient synthetic protocol under phase transfer catalytic condition has been established for the synthesis of fused tetracyclic oxazocinoquinolone analogues which served as the precursors for novel biaryl quinolones using microwave assisted Suzuki cross coupling reaction. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.06.061

文献信息

• Synthesis of novel benzoxazocino quinoliniums and quinolones under PTC conditions and their application in Suzuki cross coupling reaction for the construction of polynuclear heteroaromatics
  作者：Krishnendu B. Sahu、Abhijit Hazra、Priyankar Paira、Pritam Saha、Subhendu Naskar、Rupankar Paira、Sukdeb Banerjee、Niranjan P. Sahu、Nirup B. Mondal、Peter Luger、Manuela Weber

  DOI：10.1016/j.tet.2009.06.061

  日期：2009.8

  A general and highly efficient synthetic protocol under phase transfer catalytic condition has been established for the synthesis of fused tetracyclic oxazocinoquinolone analogues which served as the precursors for novel biaryl quinolones using microwave assisted Suzuki cross coupling reaction. (C) 2009 Elsevier Ltd. All rights reserved.