| 924888-79-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 924888-79-9
• 化学式: C₄₀H₆₄O₃Si
• 分子量: 621.032
• InChiKey: BTPAOWRSLWCTFD-QPPIDDCLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.49
• 重原子数：
  44.0
• 可旋转键数：
  19.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  27.69
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  在 咪唑 、 二苯基膦叠氮化物 、 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 为溶剂， 生成 (5S,6S)-6-azido-2,2,9,9,10,10-hexamethyl-5-pentadecyl-3,3-diphenyl-4,8-dioxa-3,9-disilaundecane
  参考文献：
  名称：

  An asymmetric synthesis of (2S,3S)-safingol

  摘要：

  Two efficient asymmetric syntheses of (2S,3S)-safingol have been developed starting from easily available (R)-cyclohexy-lideneglyceraldehyde. The key steps in the syntheses were a diastereoselective addition of a suitable alkylmagnesium or lithium reagent, and simple organic transformations. Compared to earlier syntheses, the route involving alkyllithium addition is more viable practically due to its excellent diastereoselectivity, use of inexpensive materials/reagents and operational simplicity. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.11.119
• 作为产物：
  描述：

  (R)-1,4-二氧杂螺[4,5]癸烷-2-甲醛 在 咪唑 、 lithium 作用下， 以 正己烷 、 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  An asymmetric synthesis of (2S,3S)-safingol

  摘要：

  Two efficient asymmetric syntheses of (2S,3S)-safingol have been developed starting from easily available (R)-cyclohexy-lideneglyceraldehyde. The key steps in the syntheses were a diastereoselective addition of a suitable alkylmagnesium or lithium reagent, and simple organic transformations. Compared to earlier syntheses, the route involving alkyllithium addition is more viable practically due to its excellent diastereoselectivity, use of inexpensive materials/reagents and operational simplicity. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.11.119