1,1'-Bicyclo<2.2.2>octane-1,4-diylbis | 88393-21-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1,1'-Bicyclo<2.2.2>octane-1,4-diylbis
• 英文别名: Ethanone, 1,1'-bicyclo[2.2.2]octane-1,4-diylbis-；1-(4-acetyl-1-bicyclo[2.2.2]octanyl)ethanone
• CAS: 88393-21-9
• 化学式: C₁₂H₁₈O₂
• 分子量: 194.274
• InChiKey: QWGWYJCQTJJEHN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  双环[2.2.2]辛烷-1,4-二甲醛 在 sodium hydroxide 、 sodium tetrahydroborate 、 正丁基锂 、 草酰氯 、 mercury(II) diacetate 、 二甲基亚砜 、 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 0.25h， 生成 1,1'-Bicyclo<2.2.2>octane-1,4-diylbis
  参考文献：
  名称：

  Synthesis, characterization, and chemistry of bridgehead-functionalized bicyclo[2.2.2]octanes: reactions at neopentyl sites

  摘要：

  DOI：

  10.1021/jo00178a018

文献信息

• [EN] INSULIN DIMER-INCRETIN CONJUGATES<br/>[FR] CONJUGUÉS DIMÈRES D'INSULINE-INCRÉTINE
  申请人：MERCK SHARP & DOHME

  公开号：WO2017189342A1

  公开（公告）日：2017-11-02

  Insulin dimers conjugated to peptides having at least one incretin activity are disclosed.

  已披露将胰岛素二聚体与至少具有一种胰岛素增效活性的肽共轭化。
• [EN] INSULIN RECEPTOR PARTIAL AGONISTS AND GLP-1 ANALOGUES<br/>[FR] AGONISTES PARTIELS DU RÉCEPTEUR DE L'INSULINE ET ANALOGUES DU GLP-1
  申请人：MERCK SHARP & DOHME

  公开号：WO2017205191A1

  公开（公告）日：2017-11-30

  The present invention provides compositions comprising insulin receptor partial agonists in association with GLP-1 analogues (e.g., liraglutide) as well as methods for using the compositions for example, to treat or prevent diabetes or to decrease body weight.

  本发明提供了包含胰岛素受体部分激动剂与GLP-1类似物（例如利拉鲁肽）的组合物，以及使用该组合物的方法，例如用于治疗或预防糖尿病或减轻体重。
• INSULIN RECEPTOR PARTIAL AGONISTS
  申请人：MERCK SHARP & DOHME CORP.

  公开号：EP3666792A2

  公开（公告）日：2020-06-17

  Insulin dimers and insulin analog dimers that act as partial agonists at the insulin receptor are disclosed.

  本研究公开了可作为胰岛素受体部分激动剂的胰岛素二聚体和胰岛素类似物二聚体。
• KUMAR, KANTA;WANG, SHIN, SHIN;SUKENIK, CHAIM, N., J. ORG. CHEM., 1984, 49, N 4, 665-670
  作者：KUMAR, KANTA、WANG, SHIN, SHIN、SUKENIK, CHAIM, N.

  DOI：——

  日期：——
• [EN] SMALL MOLECULE INHIBITORS OF GRP78 AND USES THEREOF<br/>[FR] INHIBITEURS À PETITES MOLÉCULES DE GRP78 ET LEURS UTILISATIONS
  申请人：[en]THE REGENTS OF THE UNIVERSITY OF MICHIGAN

  公开号：WO2022169834A2

  公开（公告）日：2022-08-11

  This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules as defined within Formula I (as defined herein) which function as inhibitors of glucose-regulated protein 78 (GRP78) within cancer cells and/or immune cells, and which function as effective therapeutic agents for treating, ameliorating, and preventing various forms of cancer (e.g., pancreatic cancer), viral infections (e.g. SARS-CoV-2), and inflammatory diseases. In addition, this invention also relates to a new class of PROTACs having Formulas II, III and IV (as defined herein) which function as degraders of GRP78 within cancer and/or immune cells. Pharmaceutical compositions comprising said compounds of Formulas I, II, III, or IV are also within the scope of the present invention.