8-methyl-6-m-tolylphenanthridine | 1356992-05-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 8-methyl-6-m-tolylphenanthridine
• CAS: 1356992-05-6
• 化学式: C₂₁H₁₇N
• 分子量: 283.373
• InChiKey: TUPTYWZSZZUFSH-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  在 palladium diacetate 、 caesium carbonate 、 三环己基膦 作用下， 以 四氢呋喃 为溶剂， 反应 24.0h， 生成 10-methyl-6-m-tolylphenanthridine 、 8-methyl-6-m-tolylphenanthridine
  参考文献：
  名称：

  Palladium-Catalyzed Intramolecular C–H Activation/C–C Bond Formation: A Straightforward Synthesis of Phenanthridines

  摘要：

  The palladium-catalyzed intramolecular C-H activation/C-C cross-coupling has been developed for a straightforward and efficient synthesis of phenanthridines. With Pd(OAc)(2) (4 mol %) as the catalyst, PCy3 (8 mol %) as the ligand, and Cs2CO3 as the base, this protocol was applied to synthesize a small library of phenanthridine derivatives in good yields in THF.

  DOI：

  10.1021/jo2017108