4-(1-{N'-(tert-butoxycarbonylamino)-N-[7-chloro-4-hydroxy-2-(pyrrolidine-1-carbonyl)-quinoline-3-carboxyl]-hydrazino}-ethyl)-benzoic acid methyl ester | 349111-17-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-(1-{N'-(tert-butoxycarbonylamino)-N-[7-chloro-4-hydroxy-2-(pyrrolidine-1-carbonyl)-quinoline-3-carboxyl]-hydrazino}-ethyl)-benzoic acid methyl ester
• 英文别名: methyl 4-[1-[[7-chloro-4-oxo-2-(pyrrolidine-1-carbonyl)-1H-quinoline-3-carbonyl]-[(2-methylpropan-2-yl)oxycarbonylamino]amino]ethyl]benzoate
• CAS: 349111-17-7
• 化学式: C₃₀H₃₃ClN₄O₇
• 分子量: 597.068
• InChiKey: HGKYEROGDQLQIA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  42
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  134
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  4-(1-{N'-(tert-butoxycarbonylamino)-N-[7-chloro-4-hydroxy-2-(pyrrolidine-1-carbonyl)-quinoline-3-carboxyl]-hydrazino}-ethyl)-benzoic acid methyl ester 在 甲烷磺酸 作用下， 以 四氢呋喃 为溶剂， 以59%的产率得到7-chloro-4-hydroxy-2-[4-(carbomethoxy)phenyl-2-ethyl]-1,2,5,10-tetrahydropyridazino[4,5-b]quinoline-1,10-dione
  参考文献：
  名称：

  Pyridazinoquinolinetriones as NMDA Glycine-Site Antagonists with Oral Antinociceptive Activity in a Model of Neuropathic Pain

  摘要：

  A series of 7-chloro-2,3-dihydro-2-[1-(pyridinyl)alkyl]-pyridazino[4,5-b]quinoline-1,4,10(5H)-triones were synthesized and found to have potent activity at the glycine site of the NMDA receptor. In some cases, these compounds possessed poor aqueous solubility that may have contributed to poor rat oral bioavailability. Subsequently, compounds have been identified with improved aqueous solubility and oral bioavailability. Several of these compounds were examined in a rat chronic constrictive injury (CCI) model of neuropathic pain and found to have potent activity when dosed orally.

  DOI：

  10.1021/jm060212s
• 作为产物：
  描述：

  7-氯-4-羟基喹啉-2,3-二羧酸二甲酯 在 氢氧化钾 、 sodium hydroxide 、 N,N'-二环己基碳二亚胺 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 19.08h， 生成 4-(1-{N'-(tert-butoxycarbonylamino)-N-[7-chloro-4-hydroxy-2-(pyrrolidine-1-carbonyl)-quinoline-3-carboxyl]-hydrazino}-ethyl)-benzoic acid methyl ester
  参考文献：
  名称：

  Pyridazinoquinolinetriones as NMDA Glycine-Site Antagonists with Oral Antinociceptive Activity in a Model of Neuropathic Pain

  摘要：

  A series of 7-chloro-2,3-dihydro-2-[1-(pyridinyl)alkyl]-pyridazino[4,5-b]quinoline-1,4,10(5H)-triones were synthesized and found to have potent activity at the glycine site of the NMDA receptor. In some cases, these compounds possessed poor aqueous solubility that may have contributed to poor rat oral bioavailability. Subsequently, compounds have been identified with improved aqueous solubility and oral bioavailability. Several of these compounds were examined in a rat chronic constrictive injury (CCI) model of neuropathic pain and found to have potent activity when dosed orally.

  DOI：

  10.1021/jm060212s

文献信息

• Compounds and methods for the treatment of pain
  申请人：Brown Gordon Dean

  公开号：US20050124622A1

  公开（公告）日：2005-06-09

  2-substituted 7-chloro-4-hydroxy-1,2,5,10-tetrahydropyridazino[4,5-b]quinoline-1,10-dione compounds, pharmaceutical compositions and methods for the treatment of pain are disclosed.

  本发明公开了2-取代的7-氯-4-羟基-1,2,5,10-四氢吡啶并[4,5-b]喹啉-1,10-二酮化合物、药物组合物和用于治疗疼痛的方法。
• COMPOUNDS AND METHODS FOR THE TREATMENT OF PAIN
  申请人：AstraZeneca AB

  公开号：EP1244661A1

  公开（公告）日：2002-10-02
• [EN] COMPOUNDS AND METHODS FOR THE TREATMENT OF PAIN<br/>[FR] COMPOSES ET METHODES DE TRAITEMENT DE LA DOULEUR
  申请人：ASTRAZENECA AB

  公开号：WO2001047926A1

  公开（公告）日：2001-07-05

  2-substituted 7-chloro-4-hydroxy-1,2,5,10-tetrahydropyridazino[4,5-b]quinoline-1,10-dione compounds, pharmaceutical compositions and methods for the treatment of pain are disclosed.