| 1358930-48-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• CAS: 1358930-48-9
• 化学式: C₁₃H₁₆ClO₅P
• 分子量: 318.694
• InChiKey: KOGWQSDTGBBNEB-DHZHZOJOSA-N

反应信息

• 作为反应物：
  描述：

  在 (S)-(-)-5,5-双(二苯膦基)-4,4-双-1,3-苯并间二氧杂环戊烯 、 copper(II) acetate monohydrate 、 叔丁醇 作用下， 以 乙醚 为溶剂， 反应 24.0h， 生成 (+)-methyl 3-(3-chlorophenyl)-4-(dimethoxyphosphoryl)butanoate 、 (-)-methyl 3-(3-chlorophenyl)-4-(dimethoxyphosphoryl)butanoate
  参考文献：
  名称：

  An enantioselective synthesis of 3-aryl-4-phosphonobutyric acid esters via Cu-catalyzed asymmetric conjugate reduction

  摘要：

  The asymmetric conjugate reduction of 3-aryl-4-phosphonobutenoates has been demonstrated which provides an enantioselective synthesis of optically active 3-aryl-4-phosphonobutyric acid esters. A wide range of 3-aryl-4-phosphonobutenoate derivates are reduced with high enantioselectivities (up to 94% ee) using an (S)-Segphos/Cu(OAc)(2)center dot H2O catalyst system (1 or 5 mol %) in the presence of PMHS and t-BuOH. The reduction is influenced by the steric and electronic effects of the substrates. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2011.12.009