epi-5-hydroxyl-1,3,2',6'-tetraazido-6,3',4'-tri-O-acetyl neamine | 948915-99-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: epi-5-hydroxyl-1,3,2',6'-tetraazido-6,3',4'-tri-O-acetyl neamine
• CAS: 948915-99-9
• 化学式: C₁₈H₂₄N₁₂O₉
• 分子量: 552.464
• InChiKey: GQKYKMBMMBDVSX-SBIRSTSESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.0
• 重原子数：
  39.0
• 可旋转键数：
  10.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  312.63
• 氢给体数：
  1.0
• 氢受体数：
  13.0

反应信息

• 作为反应物：
  描述：

  epi-5-hydroxyl-1,3,2',6'-tetraazido-6,3',4'-tri-O-acetyl neamine 在 potassium carbonate 、 1-羟基苯并三唑 、 N,N'-二环己基碳二亚胺 作用下， 以 吡啶 、 甲醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 47.5h， 生成
  参考文献：
  名称：

  Synthesis of aminodisaccharide–nucleoside conjugates for RNA binding

  摘要：

  Two types of aminodisaccharide-nucleoside conjugates were synthesized by the condensation of azidodisaccharide and nucleoside using aliphatic diamine as a linker. The corresponding azidodisaccharides could be yielded from neamine in good yield. The binding properties to 16S RNA of these conjugates were evaluated by SPR. It was found that the nucleobase played a significant role in the binding of these conjugates to 16S RNA and a shorter linker between the aminodisaccharide and nucleoside was favorable for 16S RNA binding. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2007.06.002
• 作为产物：
  描述：

  在 15-冠醚-5 、 sodium nitrite 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 以0.57 g的产率得到epi-5-hydroxyl-1,3,2',6'-tetraazido-6,3',4'-tri-O-acetyl neamine
  参考文献：
  名称：

  Synthesis of aminodisaccharide–nucleoside conjugates for RNA binding

  摘要：

  Two types of aminodisaccharide-nucleoside conjugates were synthesized by the condensation of azidodisaccharide and nucleoside using aliphatic diamine as a linker. The corresponding azidodisaccharides could be yielded from neamine in good yield. The binding properties to 16S RNA of these conjugates were evaluated by SPR. It was found that the nucleobase played a significant role in the binding of these conjugates to 16S RNA and a shorter linker between the aminodisaccharide and nucleoside was favorable for 16S RNA binding. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2007.06.002