3-羟基羽扇-20(29)烯-23,28-二酸 | 132339-62-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 中文名称: 3-羟基羽扇-20(29)烯-23,28-二酸
• 英文名称: (1R,3aS,5aR,5bR,7aR,11aR,11bR,13aR,13bR)-9-hydroxy-5a,5b,8,11a-tetramethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-3a,8-dicarboxylic acid
• CAS: 132339-62-9
• 化学式: C₃₀H₄₆O₅
• 分子量: 486.7
• InChiKey: NSLGONDVJPFEEN-YETQQTCNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.5
• 重原子数：
  35
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.87
• 拓扑面积：
  94.8
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• [EN] 23-SUBSTITUTED DERIVATIVES OF LUPANE-TYPE PENTACYCLIC TRITERPENOIDS<br/>[FR] DÉRIVÉS 23-SUBSTITUÉS DE TRITERPÉNOÏDES PENTACYCLIQUES DU TYPE LUPANE
  申请人：ADVANCED LIFE SCIENCES INC

  公开号：WO2010068668A1

  公开（公告）日：2010-06-17

  The present invention comprises small molecule inhibitors of cell proliferative conditions, in particular cancer and conditions associated with cancer. For example, associated malignancies include ovarian cancer, cervical cancer, breast cancer, colorectal cancer, and glioblastomas, among others. Accordingly, the compounds of the present invention are useful for treating, preventing, and/or inhibiting these diseases. Thus, the present invention also comprises pharmaceutical formulations comprising the compounds and methods of using the compounds and formulations to inhibit cancer and treat, prevent, or inhibit the foregoing disesases.