N'-[2-Amino-3-(4-nitro-phenyl)-propyl]-pentane-1,3-diamine | 480451-88-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N'-[2-Amino-3-(4-nitro-phenyl)-propyl]-pentane-1,3-diamine
• 英文别名: 3-N-[2-amino-3-(4-nitrophenyl)propyl]pentane-1,3-diamine
• CAS: 480451-88-5
• 化学式: C₁₄H₂₄N₄O₂
• 分子量: 280.37
• InChiKey: QCAORECTRPIALC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  20
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  110
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• (Ethylene)-(propylene) - triaminepentaacetic acid derivatives, process for their production, and their use for the production of pharmaceutical agents
  申请人：Schering AG

  公开号：US20030194371A1

  公开（公告）日：2003-10-16

  The invention relates to (ethylene)-(propylene)-triaminepentaacetic acid derivatives that are substituted on both the ethylene bridge and the propylene bridge, as well as conjugates of these compounds with biomolecules. The compounds and conjugates are suitable as agents for NMR diagnosis and radiodiagnosis as well as for radiotherapy.

  该发明涉及在乙烯桥和丙烯桥上取代的(乙烯)-(丙烯)-三胺五乙酸衍生物，以及这些化合物与生物分子的结合物。这些化合物和结合物适用于核磁共振诊断和放射诊断代理，以及放射治疗。
• (Ethylene)-( propylene)-triaminepentaacetic acid derivatives, process for their production, and their use for the production of pharmaceutical agents
  申请人：——

  公开号：US20040258620A1

  公开（公告）日：2004-12-23

  The invention relates to a novel class of ligands, complexes comprising such ligands and a metal ion, and adducts of these metal complexes and a macromolecule. Pharmaceutical compositions and methods of making and using the ligand-metal complexes are also described. The invention also relates to the use of macromolecular adducts for enhancement of diagnostic imaging. In particular, the invention relates to (ethylene)-(propylene)-triaminepentaacetic acid (EPTPA) derivatives, a process for their production, and their use for the production of pharmaceutical agents for NMR diagnosis or radiodiagnosis or radiotherapy.

  本发明涉及一类新型配体、由此类配体和金属离子组成的络合物，以及这些金属络合物和大分子的加合物。本发明还描述了配体-金属络合物的药物组合物及制造和使用方法。本发明还涉及使用大分子加合物增强诊断成像。特别是，本发明涉及(乙烯)-(丙烯)-三胺五乙酸(EPTPA)衍生物、其生产工艺及其用于生产核磁共振诊断或放射诊断或放射治疗的药剂。
• (ETHYLENE)-(PROPYLENE)-TRIAMINEPENTAACETIC ACID DERIVATIVES, PROCESS FOR THEIR PRODUCTION, AND THEIR USE FOR THE PRODUCTION OF PHARMACEUTICAL AGENTS
  申请人：Schering Aktiengesellschaft

  公开号：EP1397339A1

  公开（公告）日：2004-03-17
• [EN] (ETHYLENE)-(PROPYLENE)-TRIAMINEPENTAACETIC ACID DERIVATIVES, PROCESS FOR THEIR PRODUCTION, AND THEIR USE FOR THE PRODUCTION OF PHARMACEUTICAL AGENTS<br/>[FR] DERIVES D'ACIDE ETHYLENE PROPYLENE TRIAMINO-PENTAACETIQUE, UN PROCEDE DE PRODUCTION CORRESPONDANT, ET LEUR UTILISATION DANS LA PRODUCTION D'AGENTS PHARMACEUTIQUES
  申请人：SCHERING AG

  公开号：WO2003000647A1

  公开（公告）日：2003-01-03

  The invention relates to a novel class of ligands, complexes comprising such ligands and a metal ion, and adducts of these metal complexes and a macromolecule. Pharmaceutical compositions and methods of making and using the ligand-metal complexes are also described. The invention also relates to the use of macromolecular adducts for enhancement of diagnostic imaging. In particular, the invention relates to (ethylene)-(propylene)-triaminepentaacetic acid (EPTPA) derivatives, a process for their production, and their use for the production of pharmaceutical agents for NMR diagnosis or radiodiagnosis or radiotherapy.