Frondoside A hydrate | 127367-76-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: Frondoside A hydrate
• 英文别名: sodium;[6-[[4-acetyloxy-2,6,13,17,17-pentamethyl-6-(4-methylpentyl)-8-oxo-7-oxapentacyclo[10.8.0.02,9.05,9.013,18]icos-1(20)-en-16-yl]oxy]-5-[5-[4-[3,5-dihydroxy-6-(hydroxymethyl)-4-methoxyoxan-2-yl]oxy-3,5-dihydroxyoxan-2-yl]oxy-4-hydroxy-6-methyl-3-(3,4,5-trihydroxyoxan-2-yl)oxyoxan-2-yl]oxy-4-hydroxyoxan-3-yl] sulfate
• CAS: 127367-76-4
• 化学式: C60H95NaO29S
• 分子量: 1335.4
• InChiKey: JVAXTYZSDXFKMH-UHFFFAOYSA-M

物化性质

• 溶解度：
  H2O：≥10mg/mL

计算性质

• 辛醇/水分配系数(LogP)：
  -4.18
• 重原子数：
  91
• 可旋转键数：
  19
• 环数：
  10.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  431
• 氢给体数：
  10
• 氢受体数：
  29

文献信息

• COMPOSITION COMPRISING SEA CUCUMBER EXTRACT AS EFFECTIVE INGREDIENT FOR PREVENTING AND TREATING BRUCH'S MEMBRANE DYSFUNCTION-RELATED DISEASE
  申请人：Altregen Co., Ltd.

  公开号：EP3556373A1

  公开（公告）日：2019-10-23

  The present invention relates to a composition for preventing and treating a Bruch's membrane dysfunction-associated disease, which includes a sea cucumber extract as an active ingredient, and more particularly, to a composition for preventing and treating a Bruch's membrane dysfunction-associated disease, which includes a sea cucumber extract having effects of regenerating the Bruch's membrane of an eye and improving a transport function. The composition according to the present invention improves the transport function of the Bruch's membrane and promotes the regeneration of the Bruch's membrane, thereby delaying or reversing an eye aging process, and thus has excellent effects on the prevention and treatment of a disease such as age-related macular degeneration (AMD), Sorsby's fundus dystrophy, Malattia Levintanese (ML), Stargardt disease, Best's vitelliform retinal dystrophy and Doyne's honeycomb retinal dystrophy (DHRD), which occurs due to the age-related dysfunction of the Bruch's membrane.

  本发明涉及一种用于预防和治疗布鲁氏膜功能障碍相关疾病的组合物，其中包括作为活性成分的海参提取物，更具体地说，涉及一种用于预防和治疗布鲁氏膜功能障碍相关疾病的组合物，其中包括具有再生眼部布鲁氏膜和改善转运功能效果的海参提取物。本发明的组合物能改善布氏膜的转运功能，促进布氏膜的再生，从而延缓或逆转眼睛的衰老过程，因此对预防和治疗老年性黄斑变性（AMD）等疾病有很好的效果、索斯比眼底营养不良症、Malattia Levintanese (ML)、Stargardt 病、Best 玻璃体视网膜营养不良症和 Doyne 蜂窝状视网膜营养不良症 (DHRD)。
• [EN] COMPOSITION COMPRISING SEA CUCUMBER EXTRACT AS EFFECTIVE INGREDIENT FOR PREVENTING AND TREATING BRUCH'S MEMBRANE DYSFUNCTION-RELATED DISEASE<br/>[FR] COMPOSITION COMPRENANT DE L'EXTRAIT DE CONCOMBRE DE MER COMME INGRÉDIENT EFFICACE POUR PRÉVENIR ET TRAITER LA MALADIE LIÉE AU DYSFONCTIONNEMENT DE LA MEMBRANE DE BRUCH<br/>[KO] 해삼 추출물을 유효성분으로 하는 브루크막 기능 저하 관련 질병 예방 및 치료용 조성물
  申请人：ALTREGEN CO LTD

  公开号：WO2018117572A1

  公开（公告）日：2018-06-28

  본 발명은 해삼 추출물을 유효성분으로 하는 브루크막 기능 저하 관련 질병 예방 및 치료용 조성물에 관한 것으로서, 보다 구체적으로는 눈의 브루크막을 재생시키고, 수송기능을 개선시키는 효과를 갖는 해삼 추출물을 포함하는 브루크막 기능 저하와 관련된 질병의 예방 및 치료용 조성물 관한 것이다. 본 발명에 따른 조성물은 브루크막의 수송 기능을 개선시키고, 브루크막의 재생을 촉진시킴으로써 눈의 노화 과정을 늦추거나 되돌리는 효과가 있어, 노화에 따른 브루크막의 기능 저하로 인하여 발생하는 나이 관련 황반 변성(AMD), 소르스비 안저 이영양증(Sorsby's fundus dystrophy), ML(Malattia Levintanese), 스타가트병 (Stargardt disease), 베스트 노른자 모양 황반 이영양증(Best's vitelliform retinal dystrophy) 또는 DHRD(Doyne's honeycomb retinal dystrophy) 와 같은 질병의 예방 및 치료가 뛰어나다.