3-O-(α-L-arabinopyranosyl)oleanolic acid 28-O-(α-L-arabinopyranosyl) ester | 1039398-73-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 3-O-(α-L-arabinopyranosyl)oleanolic acid 28-O-(α-L-arabinopyranosyl) ester
• 英文别名: [(2S,3R,4S,5S)-3,4,5-trihydroxyoxan-2-yl] (4aS,6aR,6aS,6bR,8aR,10S,12aR,14bS)-2,2,6a,6b,9,9,12a-heptamethyl-10-[(2S,3R,4S,5S)-3,4,5-trihydroxyoxan-2-yl]oxy-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylate
• CAS: 1039398-73-6
• 化学式: C₄₀H₆₄O₁₁
• 分子量: 720.942
• InChiKey: UQSMOQBGYDDOME-JDFRCUGSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  51
• 可旋转键数：
  5
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  175
• 氢给体数：
  6
• 氢受体数：
  11

文献信息

• USE OF URSOLIC ACID SAPONIN,OLEANOLIC ACID SAPONIN IN PREPARATION OF INCREASING LEUCOCYTES AND/OR PLATELET MEDICINE
  申请人：Guang Bing

  公开号：US20100197898A1

  公开（公告）日：2010-08-05

  The invention provides the use of ursolic acid saponin and oleanolic acid saponin of formula (I) in preparing medicaments for increasing leucocytes and/or platelets. The invention also provides a pharmaceutical composition containing the same compound. The invention utilizes the cheap and accessible ursolic acid and oleanolic acid which are widely present in natural plants as raw materials, introduces monosaccharyls or oligosaccharyls by structural modification. It is proved by pharmacological tests that the compound of formula (I) have an activity of obviously increasing leucocytes and/or platelets.

  本发明提供了使用式(I)的熊果酸皂苷和齐墩果酸皂苷制备增加白细胞和/或血小板的药物的方法。本发明还提供了含有相同化合物的制药组合物。本发明利用廉价且易得的熊果酸和齐墩果酸，它们广泛存在于天然植物中作为原料，并通过结构修饰引入单糖或寡糖。药理学试验证明，式(I)化合物具有明显增加白细胞和/或血小板的活性。
• US8394776B2
  申请人：——

  公开号：US8394776B2

  公开（公告）日：2013-03-12