tert-butyl 2-(4-(2,2,2-trifluoroacetyl)phenoxy)acetate | 1351283-01-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: tert-butyl 2-(4-(2,2,2-trifluoroacetyl)phenoxy)acetate
• CAS: 1351283-01-6
• 化学式: C₁₄H₁₅F₃O₄
• 分子量: 304.266
• InChiKey: RAAHHHKSXOTOCJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.15
• 重原子数：
  21.0
• 可旋转键数：
  4.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  52.6
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  tert-butyl 2-(4-(2,2,2-trifluoroacetyl)phenoxy)acetate 在 吡啶 、 盐酸羟胺 作用下， 反应 0.67h， 以90%的产率得到tert-butyl 2-(4-(2,2,2-trifluoro-1-(hydroxyimino)ethyl)phenoxy)acetate
  参考文献：
  名称：

  A generic small-molecule microarray immobilization strategy

  摘要：

  Small-molecule microarrays are often limited by the requirement for each compound undergoing immobilization to contain a common functional group or by the need to prepare glass slides containing photo-reactive groups. Herein, we present a generic strategy that allows any compound library to be immobilized. This was achieved by printing a fluorous-tagged photo-reactive 3-aryl-3-trifluoromethyldiazirine, which undergoes non-selective insertion into compounds following UV-activation, onto fluorous-functionalized glass slides. The arrays could be reused following aqueous stripping and re-assessment of the compounds with the same protein or another target of interest. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.10.055
• 作为产物：
  描述：

  4-溴苯酚 在 正丁基锂 、 potassium carbonate 、 三乙胺 、 potassium iodide 作用下， 以 四氢呋喃 、 乙腈 为溶剂， 反应 0.67h， 生成 tert-butyl 2-(4-(2,2,2-trifluoroacetyl)phenoxy)acetate
  参考文献：
  名称：

  A generic small-molecule microarray immobilization strategy

  摘要：

  Small-molecule microarrays are often limited by the requirement for each compound undergoing immobilization to contain a common functional group or by the need to prepare glass slides containing photo-reactive groups. Herein, we present a generic strategy that allows any compound library to be immobilized. This was achieved by printing a fluorous-tagged photo-reactive 3-aryl-3-trifluoromethyldiazirine, which undergoes non-selective insertion into compounds following UV-activation, onto fluorous-functionalized glass slides. The arrays could be reused following aqueous stripping and re-assessment of the compounds with the same protein or another target of interest. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.10.055