1-(2-Amino-3-hydroxy-propyl)-cyclohexanol | 765310-88-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(2-Amino-3-hydroxy-propyl)-cyclohexanol
• 英文别名: 1-(2-Amino-3-hydroxypropyl)cyclohexan-1-ol
• CAS: 765310-88-1
• 化学式: C₉H₁₉NO₂
• 分子量: 173.255
• InChiKey: BYHOLSWVIOKCBM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  66.5
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-(2-Amino-3-hydroxy-propyl)-cyclohexanol 、 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 以74%的产率得到Hexadecanoic acid [2-(1-hydroxy-cyclohexyl)-1-hydroxymethyl-ethyl]-amide
  参考文献：
  名称：

  The preparation of simplified scyphostatin analogues using a tethered aminohydroxylation (TA) strategy

  摘要：

  The first tethered aminohydroxylation reaction employing a tertiary alcohol is reported as part of a route to prepare analogues of the naturally occurring sphingomyelinase inhibitor, scyphostatin. The tethered aminohydroxylation of 1-allylcyclohexanol produces the beta-amino alcohol product, in protected form, with the required regiochemistry. Two approaches to the installation of the lipophilic side chain are described and the successful route used to prepare five novel scyphostatin analogues, one containing the natural lower side chain. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2004.07.012
• 作为产物：
  描述：

  1-烯丙基环己基氨基甲酸酯 在 lithium hydroxide 、 potassium osmate(VI) 、 次氯酸叔丁酯 、 N,N-二异丙基乙胺 作用下， 以 甲醇 、 丙醇 、 sodium hydroxide 、 水 为溶剂， 生成 1-(2-Amino-3-hydroxy-propyl)-cyclohexanol
  参考文献：
  名称：

  The preparation of simplified scyphostatin analogues using a tethered aminohydroxylation (TA) strategy

  摘要：

  The first tethered aminohydroxylation reaction employing a tertiary alcohol is reported as part of a route to prepare analogues of the naturally occurring sphingomyelinase inhibitor, scyphostatin. The tethered aminohydroxylation of 1-allylcyclohexanol produces the beta-amino alcohol product, in protected form, with the required regiochemistry. Two approaches to the installation of the lipophilic side chain are described and the successful route used to prepare five novel scyphostatin analogues, one containing the natural lower side chain. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2004.07.012