(E)-2-[2-(4-methoxyphenyl)vinyl]-6,7-difluoro-8-acetoxyquinoline | 1432043-26-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (E)-2-[2-(4-methoxyphenyl)vinyl]-6,7-difluoro-8-acetoxyquinoline
• CAS: 1432043-26-9
• 化学式: C₂₀H₁₅F₂NO₃
• 分子量: 355.341
• InChiKey: KBCMGDSJSZVFJD-XVNBXDOJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.62
• 重原子数：
  26.0
• 可旋转键数：
  4.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  48.42
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  (E)-2-[2-(4-methoxyphenyl)vinyl]-6,7-difluoro-8-acetoxyquinoline 在 盐酸 作用下， 以 乙醇 、 水 为溶剂， 反应 10.0h， 生成 zinc(II) (E)-2-[2-(4-methoxyphenyl)vinyl]-6,7-difluoro-8-hydroxyquinolinate
  参考文献：
  名称：

  Synthesis and fluorescent properties of 2-styryl-6,7-difluoro-8-hydroxyquinoline and its Zn(II) complex

  摘要：

  A synthetic approach to 2-methyl-6,7-difluoro-8-hydroxyquinoline, a key intermediate, has been developed. 6,7-Difluoro derivative of 2-styryl substituted 8-hydroxyquinoline and its Zn(II) complex have been obtained. Effects of fluorine atoms in the benzene ring on photophysical properties of 2-styryl-8-hydroxyquinolines and their Zn(II) complexes have been studied. (C) 2013 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jfluchem.2013.03.005
• 作为产物：
  描述：

  6-氨基-2,3-二氟苯酚 在 盐酸 作用下， 以 水 为溶剂， 反应 36.0h， 生成 (E)-2-[2-(4-methoxyphenyl)vinyl]-6,7-difluoro-8-acetoxyquinoline
  参考文献：
  名称：

  Synthesis and fluorescent properties of 2-styryl-6,7-difluoro-8-hydroxyquinoline and its Zn(II) complex

  摘要：

  A synthetic approach to 2-methyl-6,7-difluoro-8-hydroxyquinoline, a key intermediate, has been developed. 6,7-Difluoro derivative of 2-styryl substituted 8-hydroxyquinoline and its Zn(II) complex have been obtained. Effects of fluorine atoms in the benzene ring on photophysical properties of 2-styryl-8-hydroxyquinolines and their Zn(II) complexes have been studied. (C) 2013 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jfluchem.2013.03.005