6-methoxy-4-methyl-8-<(1-propyl-4-phthalimidobutyl)amino>quinoline | 76367-91-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-methoxy-4-methyl-8-<(1-propyl-4-phthalimidobutyl)amino>quinoline
• 英文别名: 2-[4-[(6-methoxy-4-methylquinolin-8-yl)amino]heptyl]isoindole-1,3-dione
• CAS: 76367-91-4
• 化学式: C₂₆H₂₉N₃O₃
• 分子量: 431.535
• InChiKey: LVOFERQWCONZSY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.21
• 重原子数：
  32.0
• 可旋转键数：
  9.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  71.53
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  6-methoxy-4-methyl-8-<(1-propyl-4-phthalimidobutyl)amino>quinoline 在 肼 作用下， 以 乙醇 为溶剂， 反应 2.0h， 以40%的产率得到6-methyl-4-methyl-8-<(1-propyl-4-aminobutyl)amino>quinoline
  参考文献：
  名称：

  Synthesis and antimalarial activity of 8-[(1-alkyl-4-aminobutyl)amino]-6-methoxy-4-methylquinolines

  摘要：

  Three analogues of the causal prophylactic antimalarial primaquine were prepared and their antimalarial activity was evaluated. 8-[(1-Ethyl-4-aminobutyl)amino]-6-methoxy-4-methylquinoline (2a) demonstrated activity against Plasmodium berghei in mice at 20 mg/kg, with all animals cured at 320 mg/kg, and is without toxicity at 640 mg/kg. It also possessed outstanding causal prophylactic activity against Plasmodium cynomolgi in rhesus monkeys at very low dosages.

  DOI：

  10.1021/jm00134a019
• 作为产物：
  描述：

  1,4-dibromoheptane 在 二异丙胺 作用下， 以 乙二醇乙醚 、 乙醇 、 丙酮 为溶剂， 反应 91.0h， 生成 6-methoxy-4-methyl-8-<(1-propyl-4-phthalimidobutyl)amino>quinoline
  参考文献：
  名称：

  Synthesis and antimalarial activity of 8-[(1-alkyl-4-aminobutyl)amino]-6-methoxy-4-methylquinolines

  摘要：

  Three analogues of the causal prophylactic antimalarial primaquine were prepared and their antimalarial activity was evaluated. 8-[(1-Ethyl-4-aminobutyl)amino]-6-methoxy-4-methylquinoline (2a) demonstrated activity against Plasmodium berghei in mice at 20 mg/kg, with all animals cured at 320 mg/kg, and is without toxicity at 640 mg/kg. It also possessed outstanding causal prophylactic activity against Plasmodium cynomolgi in rhesus monkeys at very low dosages.

  DOI：

  10.1021/jm00134a019

文献信息

• YAN SHOU-JEN; CHIEN PING-LU; CHENG C. C., J. MED. CHEM.,1981, 24, NO 2, 215-217
  作者：YAN SHOU-JEN、 CHIEN PING-LU、 CHENG C. C.

  DOI：——

  日期：——