The synthesis of 5- and 6-acyl-2(1<i>H</i>)-pyrimidinones
作者:Winton D. Jones、Edward W. Huber、J. Martin Grisar、Richard A. Schnettler
DOI:10.1002/jhet.5570240456
日期:1987.7
The synthesis of 5-acyl-2(1H)-pyrimidinones is described. In addition, one example of the hitherto unknown 6-acyl-2(1H)-pyrimidinones has been prepared.
A novel convenient synthesis of 5-acyl-1,2-dihydropyrimidin-2-ones via 4-trichloromethyl-1,2,3,4-tetrahydropyrimidin-2-ones
作者:Anastasia A. Fesenko、Pavel A. Solovyev、Anatoly D. Shutalev
DOI:10.1016/j.tet.2009.11.099
日期:2010.1
A novel four-step methodology for the synthesis of 5-acyl-1,2-dihydropyrimidin-2-ones has been developed. The reaction of readily available N-[(1-acetoxy-2,2,2-trichloro)ethyl]ureas with Na-enolates of 1,3-diketones or beta-oxoesters followed by heterocyclization-dehydration of the oxoalkylureas formed gave 5-acyl-4-trichloromethyl-1,2,3,4-tetrahydtopyrimidin-2-ones. The latter, in the presence of NaH, eliminate CHCl3 to give the target compounds. (C) 2009 Elsevier Ltd. All rights reserved.
Process for production of pyrimidines
申请人:LILLY CO ELI
公开号:US02774760A1
公开(公告)日:1956-12-18
JONES, WINTON D.;HUBER, EDWARD W.;GRISAR, J. MARTIN;SCHNETTLER, RICHARD A+, J. HETEROCYCL. CHEM., 24,(1987) N 4, 1221-1223
作者:JONES, WINTON D.、HUBER, EDWARD W.、GRISAR, J. MARTIN、SCHNETTLER, RICHARD A+