2-Bromo-4-phenoxypyridine | 1352327-92-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-Bromo-4-phenoxypyridine
• 英文别名: 2-bromo-4-phenoxypyridine
• CAS: 1352327-92-4
• 化学式: C₁₁H₈BrNO
• 分子量: 250.095
• InChiKey: PEARSOQDYCLLHO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2,4-二溴吡啶 、 苯酚 在 copper(l) iodide 、 caesium carbonate 、 L-脯氨酸 作用下， 以 二甲基亚砜 为溶剂， 反应 24.0h， 以45%的产率得到4-bromo-2-phenoxypyridine
  参考文献：
  名称：

  Copper-catalyzed highly regioselective 2-aryloxylation of 2,x-dihalopyridines

  摘要：

  2,x-Dihalopyridines reacted with phenols catalyzed by CuI/TMEDA in the presence of Cs2CO3 in DMSO at 110 degrees C under nitrogen atmosphere for 24 h to afford 2-aryloxypyridines in good to high yields except p-nitrophenol. To expand this methodology, a vanilloid receptor ligand used in treatments was prepared in good yield. This method has potential utility in the synthesis of pharmaceuticals, agrochemicals and even natural products. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.10.025

文献信息

• Copper-catalyzed highly regioselective 2-aryloxylation of 2,x-dihalopyridines
  作者：Qizhong Zhou、Bin Zhang、Tieqi Du、Haining Gu、Yuyuan Ye、Huajiang Jiang、Rener Chen

  DOI：10.1016/j.tet.2012.10.025

  日期：2013.1

  2,x-Dihalopyridines reacted with phenols catalyzed by CuI/TMEDA in the presence of Cs2CO3 in DMSO at 110 degrees C under nitrogen atmosphere for 24 h to afford 2-aryloxypyridines in good to high yields except p-nitrophenol. To expand this methodology, a vanilloid receptor ligand used in treatments was prepared in good yield. This method has potential utility in the synthesis of pharmaceuticals, agrochemicals and even natural products. (C) 2012 Elsevier Ltd. All rights reserved.