(benzo[d][1,3]dioxol-5-ylmethyl)-5-(2,4-dihydroxy-5-isopropylphenyl)-N-(2-morpholinoethyl)-1H-pyrrole-2-carboxamide | 1198804-95-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (benzo[d][1,3]dioxol-5-ylmethyl)-5-(2,4-dihydroxy-5-isopropylphenyl)-N-(2-morpholinoethyl)-1H-pyrrole-2-carboxamide
• 英文别名: 1-(1,3-benzodioxol-5-ylmethyl)-5-(2,4-dihydroxy-5-propan-2-ylphenyl)-N-(2-morpholin-4-ylethyl)pyrrole-2-carboxamide
• CAS: 1198804-95-3
• 化学式: C₂₈H₃₃N₃O₆
• 分子量: 507.587
• InChiKey: NLELZKHTMJTVNS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  37
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  105
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• [EN] PYRROLE COMPUNDS THAT MODULATE HSP90 ACTIVITY<br/>[FR] COMPOSÉS DE PYRROLE QUI MODULENT L'ACTIVITÉ DE LA HSP90
  申请人：SYNTA PHARMACEUTICALS CORP

  公开号：WO2009148599A1

  公开（公告）日：2009-12-10

  The present invention relates to substituted pyrrole compounds and compositions comprising substituted pyrrole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted pyrrole compound of the invention, or a pharmaceutical composition comprising such a compound.

  本发明涉及取代吡咯化合物及包含取代吡咯化合物的组成物。本发明还涉及在需要的主体中抑制Hsp90活性的方法以及治疗高增殖性疾病（如癌症）的方法，其中包括向该主体施用本发明的取代吡咯化合物或含有该化合物的药物组合物。
• PYRROLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY
  申请人：Chimmanamada Dinesh U.

  公开号：US20110144103A1

  公开（公告）日：2011-06-16

  The present invention relates to substituted pyrrole compounds and compositions comprising substituted pyrrole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted pyrrole compound of the invention, or a pharmaceutical composition comprising such a compound.
• US8450500B2
  申请人：——

  公开号：US8450500B2

  公开（公告）日：2013-05-28
• US8785658B2
  申请人：——

  公开号：US8785658B2

  公开（公告）日：2014-07-22
• US9067884B2
  申请人：——

  公开号：US9067884B2

  公开（公告）日：2015-06-30