An investigation of the use of an azaheterocycle, acridine, as an alternative photochemically removable protecting group for the carboxylic function of neurotransmitteramino acids was carried out. 9-Bromomethylacridine was used in the reaction with glycine, alanine, glutamic acid, β-alanine and γ-aminobutyric acid, to obtain model ester derivatives, which were irradiated at different wavelengths in
进行了氮杂杂环,a啶作为神经递质
氨基酸的羧基功能的另一种可光
化学去除的保护基的研究。 9-
溴甲基ac啶 被用于与 甘
氨酸, 丙
氨酸, 谷
氨酸,
β-丙氨酸 和 γ-
氨基
丁酸,得到模型酯衍
生物,将其在光
化学反应器中以不同的波长进行辐照。该过程之后是HPLC / UV,导致活性分子在较短的照射时间内释放。使用419 nm辐照获得的结果显示有希望(35–98分钟)用于实际目的。通过时间分辨荧光进一步表征化合物,以阐明其光物理性质并确定衰变动力学。