maklamicin | 1283097-20-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: maklamicin
• CAS: 1283097-20-0
• 化学式: C₃₂H₄₄O₆
• 分子量: 524.698
• InChiKey: IQLRDTYLDFKBLR-KJURRLFSSA-N

反应信息

• 作为反应物：
  描述：

  maklamicin 在 吡啶 作用下， 以 甲醇 、 乙醚 、 氯仿 为溶剂， 反应 18.25h， 生成 [(1S,3R,6R,8E,10R,11S,14S,16S,19R,20S)-25-methoxy-6,10,16,20-tetramethyl-21,23-dioxo-3-[(2R)-2-[(2R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoyl]oxypropyl]-24-oxapentacyclo[20.2.1.01,6.011,20.014,19]pentacosa-4,8,12,22(25)-tetraen-4-yl]methyl (2R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate
  参考文献：
  名称：

  Maklamicin, an Antibacterial Polyketide from an Endophytic Micromonospora sp.

  摘要：

  A new spirotetronate-class polyketide, maklamicin (1), was isolated from the culture extract. of an endophytic actinomycete of the genus Micromonospora. The structure and relative configuration of were elucidated by interpretation of NMR and other spectroscopic data, and the absolute configuration was determined using the Modified Mosher method: Maklamicin (1) showed strong to modest antimicrobial activity against Gram-positive bacteria.

  DOI：

  10.1021/np100727h