4-甲氧基-6-甲基-2-吡啶甲腈 | 235742-74-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 4-甲氧基-6-甲基-2-吡啶甲腈
• 英文名称: 2-cyano-3-methoxy-6-methylpyridine
• 英文别名: 4-methoxy-6-methylpicolinonitrile；6-cyano-4-methoxy-2-picoline；4-methoxy-6-methylpyridine-2-carbonitrile
• CAS: 235742-74-2
• 化学式: C₈H₈N₂O
• 分子量: 148.164
• InChiKey: SHKCNFCBZPVUBC-UHFFFAOYSA-N

物化性质

• 沸点：
  275.8±40.0 °C(Predicted)
• 密度：
  1.12±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  45.9
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  L-叔亮氨醇 、 4-甲氧基-6-甲基-2-吡啶甲腈 在 zinc(II) chloride 作用下， 以 氯苯 为溶剂， 反应 24.0h， 以72%的产率得到(S)-2-<4,5-dihydro-4-(1,1-dimethylethyl)oxazol-2-yl>-4-methoxy-6-methylpyridine
  参考文献：
  名称：

  Remote electronic control of the ligand in the enantioselective palladium-catalyzed allylic alkylation with chiral oxazolinylpyridines

  摘要：

  New chiral oxazolinylpyridines bearing electron-donating and withdrawing groups lin the 4-position of the pyridine ring have been prepared and assessed in the enantioselective palladium catalyzed allylic substitution of 1,3-diphenylprop-2-enyl acetate with dimethyl malonate. The electronic properties of substituents strongly affect the catalytic activity and only slightly affect the enantioselectivity of the substitution reaction. Enantioselectivity up to 93% was obtained. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(99)00116-0
• 作为产物：
  描述：

  6-甲基-4-硝基-2-氰基吡啶 以 四氢呋喃 、 甲醇 、 水 、 乙酸乙酯 为溶剂， 以85.2%的产率得到4-甲氧基-6-甲基-2-吡啶甲腈
  参考文献：
  名称：

  N-(phenylsulfonyl)picolinamide derivatives, process for producing the same, and herbicide

  摘要：

  一种除草剂，其活性成分为一种由通式（I）表示的N-(苯基磺酰基)吡啶甲酰胺衍生物，其中X代表卤素、C1-4烷基、C1-4卤代烷基、C1-4烷氧基、C1-4卤代烷氧基、(C1-4烷氧基)羰基、[二(C1-4烷基)氨基]磺酰基、[N-(C1-4烷基)-N-(C1-4烷氧基)氨基]磺酰基、(C1-4烷基氨基)磺酰基、C1-4烷基硫醚、C1-4烷基亚砜基、C1-4烷基磺酰基或硝基；n为0至5的整数；Y代表卤素、C1-4烷基、C1-4卤代烷基、C1-4烷氧基、C1-4卤代烷氧基、C1-4烷基硫醚、C1-4卤代烷基硫醚、氨基、C1-4烷基氨基、二(C1-4烷基)氨基、(C1-4烷氧基)C1-4烷基、(C1-4烷基硫醚)C1-4烷基或硝基；m为0至4的整数。该活性成分通过将取代吡啶甲酸与取代苯磺酰胺在脱水条件下缩合合成，或者在碱性化合物存在下，将取代吡啶甲酸的苯酯与取代苯磺酰胺反应而制备。

  公开号：

  US06610853B1

文献信息

• <i>sp</i> ^<i>3</i> <i>Bis</i> ‐Organometallic Reagents via Catalytic 1,1‐Difunctionalization of Unactivated Olefins
  作者：Shang‐Zheng Sun、Laura Talavera、Philipp Spieß、Craig S. Day、Ruben Martin

  DOI：10.1002/anie.202100810

  日期：2021.5.17

  A catalytic 1,1‐difunctionalization of unactivated olefins en route to sp3 bis‐organometallic B,B(Si)‐reagents is described. The protocol is characterized by exceptional reaction rates, mild conditions, wide scope, and exquisite selectivity pattern, constituting a new platform to access sp3 bis‐organometallics.

  描述了未活化烯烃在sp 3 双-有机金属B，B（Si）-试剂中的催化1,1-双官能化。该方案的特点是反应速度快，条件温和，范围广，选择性强，构成了一个新的访问sp 3 bis organometallics的平台。
• N-(PHENYLSULFONYL) PICOLINAMIDE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, AND HERBICIDE
  申请人：KUREHA KAGAKU KOGYO KABUSHIKI KAISHA

  公开号：EP1069112A1

  公开（公告）日：2001-01-17

  A herbicide comprising as the active ingredient an N-(phenylsulfonyl)picolinamide derivative represented by the following general formula. This ingredient is synthesized by condensing a substituted picolinic acid with a substituted benzenesulfonamide or reacting a substituted picolinic phenyl ester with a substituted benzenesulfonamide in the presence of a basic compound: wherein X represents halogen atom, C1-C4 alkyl group, C1-C4 haloalkyl group, C1-C4 alkoxy group, C1-C4 haloalkoxy group, (C1-C4 alkoxy)carbonyl group, (di-C1-C4 alkylamino)sulfonyl group, [N-(C1-C4 alkyl)-N-(C1-C4 alkoxy)amino]sulfonyl group, (C1-C4 alkylamino)sulfonyl group, C1-C4 alkylthio group, C1-C4 alkylsulfinyl group, C1-C4 alkylsulfonyl group or nitro group, n is an integer of 0 - 5, Y represents halogen atom, C1-C4 alkyl group, C1-C4 haloalkyl group, C1-C4 alkoxy group, C1-C4 haloalkoxy group, C1-C4 alkylthio group, C1-C4 haloalkylthio group, amino group, C1-C4 alkylamino group, di-C1-C4 alkylamino group, (C1-C4 alkoxy) C1-C4 alkyl group, (C1-C4 alkylthio) C1-C4 alkyl group or nitro group, m is an integer of 0 - 4.

  一种除草剂，其活性成分为由下式通式表示的 N-(苯磺酰基)吡啶酰胺衍生物。这种成分是通过将取代的吡啶甲酸与取代的苯磺酰胺缩合或将取代的吡啶苯基酯与取代的苯磺酰胺在碱性化合物存在下反应而合成的： 其中 X 代表卤素原子、C1-C4 烷基、C1-C4 卤代烷基、C1-C4 烷氧基、C1-C4 卤代烷氧基、(C1-C4 烷氧基)羰基、(二-C1-C4 烷基氨基)磺酰基、[N-(C1-C4 烷基)-N-(C1-C4 烷氧基)氨基]磺酰基、(C1-C4 烷基氨基)磺酰基、C1-C4 烷硫基、C1-C4 烷基亚磺酰基、C1-C4 烷基磺酰基或硝基，n 为 0-5 的整数、 Y 代表卤素原子、C1-C4 烷基、C1-C4 卤代烷基、C1-C4 烷氧基、C1-C4 卤代烷氧基、C1-C4 烷硫基、C1-C4 卤代烷硫基、氨基、C1-C4 烷基氨基、二 C1-C4 烷基氨基、(C1-C4 烷氧基) C1-C4 烷基、(C1-C4 烷硫基) C1-C4 烷基或硝基、 m 是 0 - 4 的整数。
• Remote electronic control of the ligand in the enantioselective palladium-catalyzed allylic alkylation with chiral oxazolinylpyridines
  作者：Giorgio Chelucci、Sebastiano P Deriu、Antonio Saba、Raffaela Valenti

  DOI：10.1016/s0957-4166(99)00116-0

  日期：1999.4

  New chiral oxazolinylpyridines bearing electron-donating and withdrawing groups lin the 4-position of the pyridine ring have been prepared and assessed in the enantioselective palladium catalyzed allylic substitution of 1,3-diphenylprop-2-enyl acetate with dimethyl malonate. The electronic properties of substituents strongly affect the catalytic activity and only slightly affect the enantioselectivity of the substitution reaction. Enantioselectivity up to 93% was obtained. (C) 1999 Elsevier Science Ltd. All rights reserved.
• US6610853B1
  申请人：——

  公开号：US6610853B1

  公开（公告）日：2003-08-26
• N-(phenylsulfonyl)picolinamide derivatives, process for producing the same, and herbicide
  申请人：Kureha Kagaku Kogyo K.K.

  公开号：US06610853B1

  公开（公告）日：2003-08-26

  A herbicide containing as the active ingredient an N-(henylsulfonyl)picolinamide derivative represented by general formula (I) wherein X reprcsents a halogeno, a C1-4 alkyl, a C1-4 haloalkyl, a C1-4 alkoxy, a C1-4 haloalkoxy, a (C1-4 alkoxy)carbonyl, a [di(C1-4 alkyl)amino]sulfonyl, an [N—(C1-4 alkyl)-N—(C1-4 alkoxy)amino]sulfonyl, a (C1-4 alkylamino)sulfonyl, a C1-4 alkylthio, a C1-4 alkylsulfinyl, a C1-4 alkylsulfonyl, or nitro; n is an integer of 0 to 5; Y represets a halogeno, a C1-4 alkyl, a C1-4 haloalkyl, a C1-4 alkoxy, C1-4 haloalkoxy, a C1-4 alkylthio, a C1-4 haloalkylthio, amino, a C1-4 alkylamino, a di(C1-4 alkyl)amino, a (C1-4 alkoxy) C1-4 alkyl, a (C1-4 alkylthio) C1-4 alkyl, or nitro; and m is an integer of 0 to 4. This active ingredient is synthesized by condensing a substituted picolinic acid with a substituted benzenesulfonamide under dehydration, or by reacting the phenyl ester of a substituted picolinic acid with a substituted benzenesulfonamide in the presence of a basic compound.

  一种除草剂，其活性成分为一种由通式（I）表示的N-(苯基磺酰基)吡啶甲酰胺衍生物，其中X代表卤素、C1-4烷基、C1-4卤代烷基、C1-4烷氧基、C1-4卤代烷氧基、(C1-4烷氧基)羰基、[二(C1-4烷基)氨基]磺酰基、[N-(C1-4烷基)-N-(C1-4烷氧基)氨基]磺酰基、(C1-4烷基氨基)磺酰基、C1-4烷基硫醚、C1-4烷基亚砜基、C1-4烷基磺酰基或硝基；n为0至5的整数；Y代表卤素、C1-4烷基、C1-4卤代烷基、C1-4烷氧基、C1-4卤代烷氧基、C1-4烷基硫醚、C1-4卤代烷基硫醚、氨基、C1-4烷基氨基、二(C1-4烷基)氨基、(C1-4烷氧基)C1-4烷基、(C1-4烷基硫醚)C1-4烷基或硝基；m为0至4的整数。该活性成分通过将取代吡啶甲酸与取代苯磺酰胺在脱水条件下缩合合成，或者在碱性化合物存在下，将取代吡啶甲酸的苯酯与取代苯磺酰胺反应而制备。