3-hydroxy-3-methylundec-1-yne | 24424-77-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-hydroxy-3-methylundec-1-yne
• 英文别名: Methyl-n-octylaethinylcarbinol；3-Hydroxy-3-methyl-undec-1-yne；3-methylundec-1-yn-3-ol
• CAS: 24424-77-9
• 化学式: C₁₂H₂₂O
• 分子量: 182.306
• InChiKey: PDHZEDLZPIMDSR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  13
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-hydroxy-3-methylundec-1-yne 在 三(2-呋喃基)膦 、 [Rh(hydridotris(pyrazolyl)borate)(C2H4)2] 、 叔丁基肼 作用下， 以 1,4-二氧六环 为溶剂， 反应 6.0h， 以86%的产率得到3-hydroxy-3-methylundecanenitrile
  参考文献：
  名称：

  TpRh（C 2 H 4）2 / P（2-呋喃基）3催化将3,3,3-三取代丙-1-炔与叔丁基肼转化为3,3,3-三取代丙腈

  摘要：

  TpRh（C 2 H 4）2（Tp =三（吡唑-1-基）硼酸酯）和P（2-呋喃基）3的组合催化叔烷基取代的炔烃与叔丁基肼的反应，导致形成3，3，3-三取代的丙腈衍生物。该反应体系适用于1，1-二取代的炔丙醇和胺，分别得到相应的β-氰醇和β-氨基腈。催化循环涉及形成乙烯基亚乙基络合物作为关键中间体。

  DOI：

  10.1021/acs.joc.6b00116

文献信息

• Solvent-Dependent Assembly and Magnetic Relaxation Behaviors of [Cu₄I₃] Cluster-Based Lanthanide MOFs: Acting as Efficient Catalysts for Carbon Dioxide Conversion with Propargylic Alcohols
  作者：Zhi-Lei Wu、Ai-Ling Gu、Ning Gao、Hui-Ya Cui、Wen-Min Wang、Jian-Zhong Cui

  DOI：10.1021/acs.inorgchem.0c02050

  日期：2020.10.19

  generating into three-dimensional frameworks with an open 1D channel along the a axis. 1 and 2 display extensive and excellent solvent stability. Magnetic studies of 1 and 2 indicate that they exhibit interesting solvent-dependent magnetization dynamics. Importantly, 1 and 2 can act as highly effective catalysts for the carboxylic cyclization of propargyl alcohols with carbon dioxide (CO2) under ambient

  两个结构相似的金属有机骨架（MOF）[Dy 2 Cu 4 I 3（IN）7（DMF）2 ]·DMF（1）和[Dy 2 Cu 4 I 3（IN）7（DMA）2 ]·DMA （2）通过调节反应体系中的溶剂类型，成功地分离出羽化了不同配位溶剂分子的（HIN =异烟酸）。结构测试表明1和2均由1D Dy（III）链和碘化铜簇[Cu 4 I 3]生成三维框架，并沿a轴打开一维通道。1和2显示出广泛而优异的溶剂稳定性。磁性研究1和2表明，它们表现出有趣的溶剂依赖性磁化动力学。重要的是，在环境操作条件下，1和2可以用作高效炔丙基醇与二氧化碳（CO 2）羧基环化的催化剂。此外，对化合物1的底物范围进行了进一步探讨基于最佳条件，它显示出各种末端炔丙基醇与CO 2的有效环状羧化反应。该研究为MOFs材料的溶剂引导合成提供了一种有效的方法，并提出了MOFs在CO 2化学转化中的巨大应用价值。
• Highly Efficient Conversion of Propargylic Alcohols and Propargylic Amines with CO ₂ Activated by Noble‐Metal‐Free Catalyst Cu ₂ O@ZIF‐8
  作者：Ai‐Ling Gu、Ya‐Xin Zhang、Zhi‐Lei Wu、Hui‐Ya Cui、Tian‐Ding Hu、Bin Zhao

  DOI：10.1002/anie.202114817

  日期：2022.5.2

  noble-metal-free catalyst Cu2O@ZIF-8 with a yolk–shell structure was synthesized, and it represents the first noble-metal-free catalyst that can effectively catalyze both propargylic alcohols and propargylic amines with CO2 under mild conditions.

  合成了具有蛋黄壳结构的无贵金属催化剂Cu 2 O@ZIF-8，它代表了第一个在温和条件下能有效催化炔丙醇和炔丙胺与CO 2的无贵金属催化剂.
• 8,12-Dialkyl-PGE, and PGF.sub.1.sub..alpha.
  申请人：The Upjohn Company

  公开号：US03953499A1

  公开（公告）日：1976-04-27

  Prostaglandins E.sub.1 -type and F.sub.1 -type compounds of the formula ##EQU1## wherein R is hydrogen or a hydrocarbyl group containing from 1 to 12 carbon atoms, inclusive, wherein W is ##EQU2## or O =, wherein R.sub.7, R.sub.8, R.sub.9, R.sub.10, R.sub.11, R.sub.12, R.sub.13, and R.sub.14 are hydrogen or alkyl of 1 to 4 carbon atoms, inclusive, provided (1) that at least one of R.sub.7, R.sub.8, R.sub.9, R.sub.10, R.sub.11, R.sub.12, R.sub.13, and R.sub.14 is alkyl (2) that when R.sub.13 is alkyl, at least one of R.sub.7, R.sub.8, R.sub.9, R.sub.10, R.sub.11, R.sub.12, and R.sub.14 is alkyl, and (3) that when R.sub.7 is alkyl or thwn R.sub.7 and R.sub.8 are alkyl, at least one of R.sub.9, R.sub.10, R.sub.11, R.sub.12, R.sub.13, and R.sub.14 is alkyl; and the enantiomers and racemic mixtures thereof. These are useful for the same pharmacological purposes as the unsubstituted prostaglandins.

  该文描述了一种公式为##EQU1##的前列腺素E.sub.1型和F.sub.1型化合物，其中R为氢或含1到12个碳原子（包括）的烃基，W为##EQU2##或O =，其中R.sub.7，R.sub.8，R.sub.9，R.sub.10，R.sub.11，R.sub.12，R.sub.13和R.sub.14为氢或1到4个碳原子（包括）的烷基，前提是（1）R.sub.7，R.sub.8，R.sub.9，R.sub.10，R.sub.11，R.sub.12，R.sub.13和R.sub.14中至少有一个为烷基（2）当R.sub.13为烷基时，R.sub.7，R.sub.8，R.sub.9，R.sub.10，R.sub.11，R.sub.12和R.sub.14中至少有一个为烷基，（3）当R.sub.7为烷基或当R.sub.7和R.sub.8为烷基时，R.sub.9，R.sub.10，R.sub.11，R.sub.12，R.sub.13和R.sub.14中至少有一个为烷基；以及它们的对映异构体和混合物。这些化合物可用于与未取代的前列腺素相同的药理学目的。
• Intrinsic Inhibition of Aldose Reductase
  作者：Peter F. Kador、Guoping Sun、Vladimir K. Rait、Libaniel Rodriguez、Ying Ma、Katsumi Sugiyama

  DOI：10.1089/108076801753162780

  日期：2001.8

  The development of aldose reductase inhibitors for the treatment of diabetic complications, such as cataract and retinopathy, has been of intense interest in the pharmaceutical community for the last 20 years. To date, aldose reductase inhibitors have been synthetically developed from leads obtained from in vitro screening studies. Recently, we have observed that mammalian tissues contain intrinsic inhibitors of aldose reductase, which may be used as potential drugs for treating diabetic complications with potentially less side effects than synthetic aldose reductase inhibitors. Intrinsic inhibitor(s) of aldose reductase have been observed in the methanolic extracts from rat and human kidneys and bovine lenses that were subjected to a number of chromatographic techniques, including counter current chromatography, flash chromatography, gel filtration and high pressure liquid chromatography. This inhibition results from a direct interaction between the inhibitor and enzyme. The intrinsic inhibitor, present in the lipophilic fraction of human kidney and bovine lens extracts, can easily penetrate into the lens to inhibit sugar alcohol formation. Intraperitoneal injection of partially purified bovine lens extract inhibited lens polyol formation in young rats fed 50% galactose diet.
• Detecting photosynthetic algal pigments in natural populations using a high-spectral-resolution spectroradiometer
  作者：R. Aguirre-Gomez、S. R. Boxall、A. R. Weeks

  DOI：10.1080/01431160120387

  日期：2001.1

  Reflectance data from a high spectral resolution spectroradiometer were obtained onboard a ship in Plymouth coastal waters. These data were analysed to detect algal photosynthetic accessory pigments for comparison with absorption spectra as measured in the laboratory by a spectrophotometer. The overall spectral characteristics of Plymouth waters allowed identification as to population composition, Derivative analysis of the spectra was used to resolve characteristic peaks of specific pigments. It was determined that chlorophyll pigments, a specific carotenoid and sea water absorption bands were detectable in the reflectance data. Absorption bands of photosynthetic and accessory pigments were assessed through chromatographic pigment analysis.