7-chloro-4-[N-(4-N',N'-diethylamino)-1-methyl-butylamino]-1-ferrocenylmethylquinolinium iodide | 252578-94-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 7-chloro-4-[N-(4-N',N'-diethylamino)-1-methyl-butylamino]-1-ferrocenylmethylquinolinium iodide
• 英文别名: 4-N-[7-chloro-1-(cyclopenta-1,3-dien-1-ylmethyl)quinolin-1-ium-4-yl]-1-N,1-N-diethylpentane-1,4-diamine;cyclopenta-1,3-diene;iron(2+);iodide
• CAS: 252578-94-2
• 化学式: C₂₉H₃₇ClFeN₃*I
• 分子量: 645.837
• InChiKey: XQFIXVLRPOTZOM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
  None
• sp3杂化的碳原子比例：
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• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  L-酒石酸 、 7-chloro-4-[N-(4-N',N'-diethylamino)-1-methyl-butylamino]-1-ferrocenylmethylquinolinium iodide 以 丙酮 为溶剂， 以90%的产率得到7-chloro-4-[N-(4-N',N'-diethylamino)-1-methyl-butylamino]-1-ferrocenylmethylquinolinium bi-tartrate
  参考文献：
  名称：

  Novel metallocenic compounds as antimalarial agents. Study of the position of ferrocene in chloroquine

  摘要：

  The synthesis, characterization and antimalarial activity of two new ferrocene-chloroquine compounds are reported. One of them, 7-chloro-4-N-[(4-N'-ethyl-N'-ferrocenylmethyl)ammonio-1-methylbutylamino]quinolin-1-ium bi-tartrate (2) showed very promising antimalarial activity in vivo on mice infected with Plasmodium berghei N. and Plasmodium yoelii NS. and in vitro against chloroquine resistant-strains of Plasmodium falciparum. (C) 1999 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0022-328x(99)00302-2
• 作为产物：
  描述：

  N,N,N-(ferrocenylmethyl)trimethylammonium iodide 、 氯喹 在 potassium carbonate 作用下， 以 乙腈 为溶剂， 以53%的产率得到7-chloro-4-[N-(4-N',N'-diethylamino)-1-methyl-butylamino]-1-ferrocenylmethylquinolinium iodide
  参考文献：
  名称：

  Novel metallocenic compounds as antimalarial agents. Study of the position of ferrocene in chloroquine

  摘要：

  The synthesis, characterization and antimalarial activity of two new ferrocene-chloroquine compounds are reported. One of them, 7-chloro-4-N-[(4-N'-ethyl-N'-ferrocenylmethyl)ammonio-1-methylbutylamino]quinolin-1-ium bi-tartrate (2) showed very promising antimalarial activity in vivo on mice infected with Plasmodium berghei N. and Plasmodium yoelii NS. and in vitro against chloroquine resistant-strains of Plasmodium falciparum. (C) 1999 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0022-328x(99)00302-2