| 226074-36-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 226074-36-8
• 化学式: C₇₉H₁₀₉Cl₂NO₃₈
• 分子量: 1751.62
• InChiKey: DPEMQRBCXAQCKM-VUGBKTSTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.84
• 重原子数：
  120.0
• 可旋转键数：
  30.0
• 环数：
  13.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  446.1
• 氢给体数：
  5.0
• 氢受体数：
  38.0

反应信息

• 作为反应物：
  描述：

  在 bis-triphenylphosphine-palladium(II) chloride 、 三正丁基氢锡 作用下， 以 四氢呋喃 为溶剂， 反应 0.25h， 以67%的产率得到
  参考文献：
  名称：

  Chemical modifications and structure activity studies of ziracin and related everninomicin antibiotics

  摘要：

  Chemical modifications of everninomicin antibiotics, particularly ziracin (1), were carried out to study the SARs as well as the chemical properties of this class of compounds. Use of allyl ether group for protection and selective deprotection of phenolic groups provided access to a variety of novel analogs of the title compounds, some of which exhibited the same high in vitro potency as the parent compounds. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00163-8
• 作为产物：
  描述：

  3-溴丙烯 、 依维米星 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 23.0h， 以100%的产率得到
  参考文献：
  名称：

  Chemical modifications and structure activity studies of ziracin and related everninomicin antibiotics

  摘要：

  Chemical modifications of everninomicin antibiotics, particularly ziracin (1), were carried out to study the SARs as well as the chemical properties of this class of compounds. Use of allyl ether group for protection and selective deprotection of phenolic groups provided access to a variety of novel analogs of the title compounds, some of which exhibited the same high in vitro potency as the parent compounds. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00163-8