| 1079394-10-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• CAS: 1079394-10-7
• 化学式: C₃₇H₄₃F₃O₈
• 分子量: 672.739
• InChiKey: HYIZCSQIDGTOFW-BTOHONEBSA-N

反应信息

• 作为产物：
  描述：

  5,7-dihydroxy-4-(1-hydroxypropyl)-6-(2-methyl-1-oxobutyl)-8-(3,7-dimethyl-2,6-octadienyl)-2H-benzopyran-2-one 、 甲氧基-三氟甲基苯 在 吡啶 作用下， 反应 12.0h， 以1.8 mg的产率得到
  参考文献：
  名称：

  Novel anticancer agents, kayeassamins C−I from the flower of Kayea assamica of Myanmar

  摘要：

  ACHCl(3)-soluble fraction of 70% EtOH extract of the flower of Kayea assamica from Myanmar exhibited 100% preferential cytotoxicity (PC(100)) against human pancreatic cancer PANC-1 cells under nutrient-deprived conditions at 1 mu g/mL. Bioassay-guided fractionation and isolation afforded nine new coumarins, kayeassamins A (8), B (9), and C-I (1-7), together with nine known coumarins (10-18). The structures of these compounds were identified by extensive spectroscopic techniques as well as by comparison with published data. Absolute configuration at C-1' of 1 was established as S-configuration by the modified Mosher method. All the isolates were evaluated for their in vitro preferential cytotoxicity using novel anti-austerity strategy. Amongthem, the novel coumarins, kayeassaminsA(8), B (9), D(2), E (3), and G(5) exhibited the most potent preferential cytotoxicity (PC(100) 1 mu M) in a concentration- and time-dependent manner and induced apoptosis-like morphological changes of PANC-1 cells within 24 h of treatment. Based on the observed cytotoxicity, structure-activity relationships have been established. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2008.07.091