4-(3-chloroyphenyl)-7,7-dimethyl-2-phenyl-4,6,7,8-tetrahydro-5(1H)-quinolinone | 935761-98-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-(3-chloroyphenyl)-7,7-dimethyl-2-phenyl-4,6,7,8-tetrahydro-5(1H)-quinolinone
• CAS: 935761-98-1
• 化学式: C₂₃H₂₂ClNO
• 分子量: 363.887
• InChiKey: IKHJGILXMJIHDV-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  5,5-二甲基-1,3-环己二酮 、 3-氯苯甲醛 、 苯乙酮 在 ammonium acetate 作用下， 反应 1.5h， 以92%的产率得到4-(3-chloroyphenyl)-7,7-dimethyl-2-phenyl-4,6,7,8-tetrahydro-5(1H)-quinolinone
  参考文献：
  名称：

  Cobalt Nanoparticles Promoted Highly Efficient One Pot Four-Component Synthesis of 1,4-Dihydropyridines under Solvent-Free Conditions

  摘要：

  A straightforward and general method has been developed for the synthesis of C(5)-unsubstitiuted 1,4-dihydropyridines by a reaction using dimedone, acetophenone, aromatic aldehydes, and ammonium acetate in the presence of a catalytic amount of Co nanoparticles as a heterogeneous and eco-friendly catalyst with high catalytic activity at room temperature under solvent-free conditions. This catalyst is easily separated by magnetic devices and can be reused without any apparent loss of activity for the reaction. In addition, it is very interesting that when using Co nanoparticles as a catalyst, spatially-hindered aldehydes such as 2-methoxy-, 2-fluoro-, and 2-chloro-aldehydes are suitable for this reaction.

  DOI：

  10.1016/s1872-2067(10)60295-1