glucoside acetate | 104418-77-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: glucoside acetate
• 英文别名: Glucosyl acetate；[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] acetate
• CAS: 104418-77-1
• 化学式: C₈H₁₄O₇
• 分子量: 222.195
• InChiKey: RXRFEELZASHOLV-KEWYIRBNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.7
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  116
• 氢给体数：
  4
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  glucoside acetate 、 乙酸酐 在 sodium carbonate 作用下， 以 重水 为溶剂， 生成 acetyl-β-D-glucopyranoside 、 α-D-2-O-acetyl-glucopyranose
  参考文献：
  名称：

  在水中用乙酸酐对未保护糖进行选择性异头乙酰化

  摘要：

  在存在乙酸酐和弱碱（如碳酸钠）的情况下，只需在水溶液中搅拌，即可选择性地乙酰化未受保护的糖。该反应对甘露糖、2-乙酰氨基和 2-脱氧糖的异头羟基的乙酰化具有选择性，并且可以大规模进行。当这两个取代基为顺式时， 1- O-乙酸酯分子内竞争性迁移至 2-羟基会导致过度反应并形成产物混合物。

  DOI：

  10.1021/acs.orglett.3c00584

文献信息

• Method for enantioselective hydrogenation of chromenes
  申请人：Setchell David Reginald Kenneth

  公开号：US20070027329A1

  公开（公告）日：2007-02-01

  A method for preparing an enantiomeric chromane, by asymmetrically hydrogenating a chromene compound in the presence of an Ir catalyst having a chiral ligand. The method includes the enantioselective preparation of enantiomeric equol. A preferred Ir catalyst has a chiral phosphineoxazoline ligand. Enantiomeric chromanes of high stereoselective purity can be obtained.

  一种制备对映异构体色苷的方法，通过在具有手性配体的Ir催化剂存在下，对色烯化合物进行不对称氢化。该方法包括对对映异构体色苷的对映选择性制备。首选的Ir催化剂具有手性膦氧唑啉配体。可以获得高立体选择性纯度的对映异构体色苷。
• [EN] BRANCHED ALCOHOL-BASED SUGAR SURFACTANTS<br/>[FR] TENSIOACTIFS DE SUCRE À BASE D'ALCOOL RAMIFIÉ
  申请人：DOW GLOBAL TECHNOLOGIES LLC

  公开号：WO2017058474A1

  公开（公告）日：2017-04-06

  Prepare a branched alcohol-based sugar surfactant by: (a) providing an ether alcohol and a fully acetylated sugar where the ether alcohol has the structure of Structure (I); (b) coupling the ether alcohol with the acetylated sugar in the presence of a Lewis acid catalyst to form a branched glucoside acetate; and (c) deprotecting the glucoside acetate by removing the acetate moieties and replacing them with hydrogen atoms in the presence of a base to form a surfactant having the structure (II).

  通过以下步骤制备一种分支醇基糖表面活性剂：(a)提供一种醚醇和一种完全乙酰化的糖，其中该醚醇具有结构(I)的结构；(b)在路易斯酸催化剂的存在下，将醚醇与乙酰化的糖偶联以形成分支葡萄糖苷醋酸酯；(c)在碱的存在下去保护葡萄糖苷醋酸酯，去除醋酸基团并用氢原子替换它们，形成具有结构(II)的表面活性剂。
• Compositions and products containing S-equol, and methods for their making
  申请人：——

  公开号：US20040235758A1

  公开（公告）日：2004-11-25

  A composition for use in making commercial food and skin products comprising S-equol or mixtures, including both a non-racemic mixture and a racemic mixture, of S-equol and R-equol. The composition can be used to make articles of commerce such as food supplements, pharmaceuticals, and medicaments. The compositions are useful in a method of delivering S-equol to a mammal to prevent or treat a disease or associated condition, including hormone-dependent diseases or conditions such as cardiovascular disease, lipid disorder, osteopenia, osteoporosis, liver disease, and acute ovarian estrogen deficiency. The S-equol enantiomer can be produced in a biological synthesis from the metabolism of an isoflavone by an organism.

  一种用于制作商业食品和皮肤产品的组合物，包括S-对羟基异黄酮或混合物，包括非外消旋混合物和外消旋混合物，其中包括S-对羟基异黄酮和R-对羟基异黄酮。该组合物可用于制造诸如食品补品、药品和药物等商业产品。该组合物对于通过一种方法向哺乳动物输送S-对羟基异黄酮以预防或治疗疾病或相关症状，包括激素依赖性疾病或症状，如心血管疾病、脂质紊乱、骨质疏松症、骨质疏松症、肝病和急性卵巢雌激素缺乏症，具有有用性。S-对羟基异黄酮对映体可以通过生物合成从生物体内的异黄酮代谢中产生。
• Compositions and products containing R-equol, and methods for their making
  申请人：——

  公开号：US20040147594A1

  公开（公告）日：2004-07-29

  A composition for use in making commercial food and skin products comprising R-equol. The composition can be used to make articles of commerce such as food supplements, pharmaceuticals, and medicaments. The compositions are useful in a method of delivering R-equol to a mammal to prevent or treat a disease or associated condition, including hormone-dependent diseases or conditions such as cardiovascular disease, lipid disorder, osteopenia, osteoporosis, liver disease, and acute ovarian estrogen deficiency. The R-equol enantiomer can be produced by chiral-phase column separation from a racemic mixture of equol.

  一种用于制造商业食品和皮肤产品的配方，其中包含R-伊奎醇。该配方可用于制造诸如食品补充剂、药品和药物等商业产品。该组合物在向哺乳动物提供R-伊奎醇以预防或治疗疾病或相关症状，包括激素依赖性疾病或症状，如心血管疾病、脂质紊乱、骨质疏松症、骨质疏松症、肝病和急性卵巢雌激素缺乏症方面非常有用。R-伊奎醇对映体可以通过手性相柱分离从伊奎醇的混合物中制备。
• COMPOSITIONS AND PRODUCTS CONTAINING S-EQUOL, AND METHODS FOR THEIR MAKING
  申请人：SETCHELL Kenneth David Reginald

  公开号：US20090018185A1

  公开（公告）日：2009-01-15

  A composition for use in making commercial food and skin products comprising S-equol or mixtures, including both a non-racemic mixture and a racemic mixture, of S-equol and R-equol. The composition can be used to make articles of commerce such as food supplements, pharmaceuticals, and medicaments. The compositions are useful in a method of delivering S-equol to a mammal to prevent or treat a disease or associated condition, including hormone-dependent diseases or conditions such as cardiovascular disease, lipid disorder, osteopenia, osteoporosis, liver disease, and acute ovarian estrogen deficiency. The S-equol enantiomer can be produced in a biological synthesis from the metabolism of an isoflavone by an organism.

  一种用于制造商业食品和皮肤产品的组合物，包括S-equol或S-equol和R-equol的混合物，包括非外消旋混合物和外消旋混合物。该组合物可用于制造诸如食品补充剂、药品和药物等商业用品。该组合物在传递S-equol以预防或治疗疾病或相关症状的方法中非常有用，包括激素依赖性疾病或状况，如心血管疾病、脂质紊乱、骨质疏松症、骨质疏松症、肝病和急性卵巢雌激素缺乏症。S-equol对映体可以通过生物合成从生物体内的异黄酮代谢产生。