| 1345134-37-3

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• CAS: 1345134-37-3
• 化学式: C₃₈H₆₆N₁₀O₆Si₃
• 分子量: 843.262
• InChiKey: SBLWJCUKXCFQIL-RWJWSVIKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.48
• 重原子数：
  57.0
• 可旋转键数：
  14.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.74
• 拓扑面积：
  194.62
• 氢给体数：
  2.0
• 氢受体数：
  16.0

反应信息

• 作为产物：
  描述：

  diisopropylsilanediyl bistriflate 在 2,6-二叔丁基-4-甲基吡啶 、 乙醇 、 乙二胺 作用下， 以 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 反应 2.83h， 生成
  参考文献：
  名称：

  Synthesis of dendritic oligodeoxyribonucleotide analogs with nonionic diisopropylsilyl linkage

  摘要：

  Series of new dendritic oligodeoxyribonucleotide analogs with diisopropylsilyl linkage were prepared via liquid-phase synthesis. Dendron was employed as soluble support, which facilitated purification of the products by simple solvent precipitation. Sequences leading to the dendritic octamer 5'-TSiTSiTSiTSiTSiT-(Si)T(Si)T(S)2-3' (T8D(2)) were prepared and each isolated intermediate was characterized by NMR and mass spectrometry. The recognition properties of two complementary dendritic dinucleotide analogs of TSiTSiD2 (T2D2) and A(Si)A(Si)D(2) (A2D(2)) were also studied by NMR and FT-MS spectra in a nonaqueous aprotic environment (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.09.108