dihexyl(2-methyl-4-oxopent-2-yl)phosphineoxide | 1196795-11-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: dihexyl(2-methyl-4-oxopent-2-yl)phosphineoxide
• 英文别名: Dihexyl(2-methyl-4-oxopent-2-yl)phosphine oxide；4-dihexylphosphoryl-4-methylpentan-2-one
• CAS: 1196795-11-5
• 化学式: C₁₈H₃₇O₂P
• 分子量: 316.464
• InChiKey: ADUZAJAMGDRPFJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  21
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  dihexyl(2-methyl-4-oxopent-2-yl)phosphineoxide 在 盐酸羟胺 、 sodium hydroxide 作用下， 以 乙醇 为溶剂， 以89%的产率得到dihexyl(4-hydroxyimino-2-methylpent-2-yl)phosphine oxide
  参考文献：
  名称：

  Dimephosphone analogs: II. Dialkyl(diaryl)-(2-methyl-4-oxopent-2-yl)phosphine oxide oximes: Synthesis, structure, and generation of iminoxyl radicals

  摘要：

  Dialkyl(diaryl)-(2-methyl-4-oxopent-2-yl)phosphine oxide oximes have been synthesized for the first time. According to the X-ray diffraction data, these compounds in crystal exist as a single E isomer. Their structure in solution and the E/Z isomer ratio were determined by H-1 and C-13 NMR spectroscopy.

  DOI：

  10.1134/s107036321405020x
• 作为产物：
  描述：

  2-Chlor-3,3,5-trimethyl-1,2-oxaphosphol-4-en-2-oxid 、 1-碘己烷 在 magnesium 、 盐酸 、 水 作用下， 以 乙醚 为溶剂， 以90%的产率得到dihexyl(2-methyl-4-oxopent-2-yl)phosphineoxide
  参考文献：
  名称：

  New synthesis of phosphine oxides bearing a 2-methyl-4-oxopent-2-yl substituent

  摘要：

  A new approach to the synthesis of substituted phosphine oxides bearing an oxo group at the gamma-position to the phosphorus atom was developed.

  DOI：

  10.1016/j.mencom.2010.03.007

文献信息

• Synthesis of new 2-[2-(dialkyl(diaryl)-phosphoryl)-2-methylpropyl]quinoline-4-carboxylic acids
  作者：Dmitry A. Tatarinov、Viktoria I. Osipova、Andrei V. Bogdanov、Dmitry B. Krivolapov、Alexandra D. Voloshina、Vladimir F. Mironov

  DOI：10.1007/s10593-015-1761-y

  日期：2015.8

  A Pfitzinger reaction of isatin with 2-methyl-(4-oxopent-2-yl)dialkyl(diphenyl)phosphine oxides was used to synthesize new derivatives of 4-quinolinecarboxylic acids, containing a phosphine oxide fragment, and screening for antimicrobial activity was performed.

  靛红与2-甲基-（4-氧opent-2-基）二烷基（二苯基）膦氧化物的Pfitzinger反应用于合成含有膦氧化物片段的4-喹啉羧酸的新衍生物，并进行了抗菌活性的筛选。
• 3-(4-Phosphoryl-4-methyl-2-oxopentyl)-3-hydroxyindolin-2-ones, the first phosphorus analogues of natural convolutamydines
  作者：Dmitry A. Tatarinov、Victoria I. Osipova、Andrei V. Bogdanov、Robert R. Fayzullin、Vladimir F. Mironov

  DOI：10.1016/j.mencom.2018.05.021

  日期：2018.5

  The first examples of phosphorus-containing analogues of natural alkaloids, convolutamydines, have been obtained by aldol condensation of 4-dialkyl(diphenyfiphosphoryl]-4-methylpentan-2-one with isatin. An unusually facile reversible process of dehydration-hydration of these phosphorus-containing hydroxy indoles has been discovered.