Methyl 3-(4-hydroxyphenyl)-5-isoxazoleacetate | 478336-93-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: Methyl 3-(4-hydroxyphenyl)-5-isoxazoleacetate
• 英文别名: methyl 2-[3-(4-hydroxyphenyl)-1,2-oxazol-5-yl]acetate
• CAS: 478336-93-5
• 化学式: C₁₂H₁₁NO₄
• 分子量: 233.22
• InChiKey: DUXWXZVFSBFOBA-UHFFFAOYSA-N

物化性质

• 沸点：
  397.8±32.0 °C(Predicted)
• 密度：
  1.281±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  72.6
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• ISOXAZOLINE COMPOUNDS HAVING MIF ANTAGONIST ACTIVITY
  申请人：Cytokine Pharmasciences, Inc.

  公开号：EP1411930B1

  公开（公告）日：2013-01-16
• Isoxazoline Compounds Having MIF Antagonist Activity
  申请人：Al-Abed Yousef

  公开号：US20100016391A1

  公开（公告）日：2010-01-21

  Methods of use and pharmaceutical compositions for a genus of low molecular weight compounds comprising optionally substituted isoxazoline ring systems that act as inhibitors of MIF (macrophage migration inhibitory factor) are disclosed. Specifically, the compounds are useful for treating a variety of diseases involving inflammatory activity or pro-inflammatory cytokine responses, such as autoimmune diseases (including rheumatoid arthritis, insulin-dependent diabetes, multiple sclerosis, graft versus host disease, lupus syndromes), asthma, arthritis, ARDS, psoriasis, interleukin-2 toxicity, proliferative vascular disease, and various forms of sepsis and septic shock, and other conditions characterized by underlying MIF responses including, for instance, tumor growth and neovascularization (angiogenesis).
• US7491740B2
  申请人：——

  公开号：US7491740B2

  公开（公告）日：2009-02-17
• US7662843B2
  申请人：——

  公开号：US7662843B2

  公开（公告）日：2010-02-16
• US7928130B2
  申请人：——

  公开号：US7928130B2

  公开（公告）日：2011-04-19