3-methylenenorborneol | 791067-20-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 3-methylenenorborneol
• 英文别名: 3-Methylidenebicyclo[2.2.1]heptan-2-ol
• CAS: 791067-20-4
• 化学式: C₈H₁₂O
• 分子量: 124.183
• InChiKey: HRHWYMYFFLHQCE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  3-亚甲基-2-降冰片酮 在 sodium tetrahydroborate 作用下， 以 乙醇 为溶剂， 生成 3-methylenenorborneol
  参考文献：
  名称：

  Identification and structure–activity relationship studies of 3-methylene-2-norbornanone as potent anti-proliferative agents presumably working through p53 mediated apoptosis

  摘要：

  We have identified a novel series of alpha-methylene carbonyl compounds through structure-activity relationship (SAR) studies with high levels of anti-proliferative activities. The lead molecule, 3-methylene-2-norbornanone (3) showed potent activity (LC50 = 3-8 muM) against mutant p53 cell types and many fold selectivity (>13-29) over wild-type p53 cells. Further, compound 3 and its analogs showed refolding of mutant p53 protein comparable to their anti-proliferative activities suggesting possible interaction with mutant p53 protein. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.08.048

文献信息

• METAL-FILM-COATED MATERIAL AND PROCESS FOR PRODUCING THE SAME, METALLIC-PATTERN-BEARING MATERIAL AND PROCESS FOR PRODUCING THE SAME, COMPOSITION FOR POLYMER LAYER FORMATION, NITRILE POLYMER AND METHOD OF SYNTHESIZING THE SAME, COMPOSITION CONTAINING NITRILE POLYMER, AND LAYERED PRODUCT
  申请人：FUJIFILM Corporation

  公开号：EP2078607A1

  公开（公告）日：2009-07-15

  A process for producing a metal film-coated material, the process including: (a1) forming, on a substrate, a polymer layer formed from a polymer which has a functional group capable of interacting with a plating catalyst or a precursor thereof, and is directly chemically bonded to the substrate;(a2) providing a plating catalyst or a precursor thereof to the polymer layer; and (a3) performing plating with respect to the plating catalyst or a precursor thereof. The polymer layer satisfies all of the following requirements (1) to (4): (1) the saturated water absorption coefficient of the polymer layer as measured in an environment of temperature of 25°C and relative humidity of 50 % is 0.01 to 10% by mass; (2) the saturated water absorption coefficient of the polymer layer as measured in an environment of temperature of 25°C and relative humidity of 95 % is 0.05 to 20% by mass; (3) the water absorption coefficient of the polymer layer as measured after 1 hour of immersion in boiling water at 100°C is 0.1 to 30% by mass; and (4) the surface contact angle of the polymer layer as measured after dropping 5 µL of distilled water thereonto and leaving to stand for 15 seconds in an environment of temperature of 25°C and relative humidity of 50 % is 50 to 150 degrees.

  一种生产金属薄膜涂层材料的工艺，该工艺包括：(a1) 在基底上形成聚合物层，该聚合物层由具有能与电镀催化剂或其前体相互作用的官能团的聚合物形成，并直接与基底化学键合；(a2) 向聚合物层提供电镀催化剂或其前体；(a3) 对电镀催化剂或其前体进行电镀。聚合物层满足以下所有要求（1）至（4）：(1) 在温度为 25°C、相对湿度为 50%的环境下测得的聚合物层的饱和吸水系数为 0.01 至 10%（按质量计）； (2) 在温度为 25°C、相对湿度为 95%的环境下测得的聚合物层的饱和吸水系数为 0.(3) 在 100°C 沸水中浸泡 1 小时后测得的聚合物层吸水系数为 0.1 至 30%（按质量计）；以及 (4) 在温度为 25°C 和相对湿度为 50%的环境中，滴入 5 微升蒸馏水并静置 15 秒后测得的聚合物层表面接触角为 50 至 150 度。
• Nitrile group-containing polymer and method of synthesizing the same, composition containing nitrile group-containing polymer, and laminate
  申请人：Fujifilm Corporation

  公开号：EP2105451A2

  公开（公告）日：2009-09-30

  A polymer comprising a unit represented by the following Formula (1), and a unit represented by the following Formula (2): wherein in Formula (1) and Formula (2), R1 to R5 each independently represent a hydrogen atom or a substituted or unsubstituted alkyl group; X, Y and Z each independently represent a single bond, a substituted or unsubstituted divalent organic group, an ester group, an amide group or an ether group; and L1 and L2 each independently represent a substituted or unsubstituted divalent organic group.

  一种聚合物，由下式（1）代表的单元和下式（2）代表的单元组成： 其中，在式 (1) 和式 (2) 中，R1 至 R5 各自独立地代表氢原子或取代或未取代的烷基；X、Y 和 Z 各自独立地代表单键、取代或未取代的二价有机基团、酯基、酰胺基或醚基；以及 L1 和 L2 各自独立地代表取代或未取代的二价有机基团。
• CONDUCTIVE-SUBSTANCE-ADSORBING RESIN FILM, PROCESS FOR PRODUCING CONDUCTIVE-SUBSTANCE-ADSORBING RESIN FILM, METAL-LAYER-COATED RESIN FILM MADE FROM THE SAME, AND PROCESS FOR PRODUCING METAL-LAYER-COATED RESIN FILM
  申请人：Fujifilm Corporation

  公开号：EP2133200A1

  公开（公告）日：2009-12-16

  The invention provides a conductive substance-adsorbing resin film on which a conductive layer being excellent in adhesion to the resin film and having less unevenness at the interface with the resin film can easily be formed, a method for producing the same, a metal layer-coated resin film on which a high definition wiring excellent in adhesion to the insulating resin film can easily be formed, which is obtained by using the conductive substance-adsorbing resin film of the invention, and a method for producing a metal layer-coated resin film that is a material capable of easily producing a printed-wiring board having a high definition wiring. The invention also provides a conductive substance-adsorbing resin film including at least two resin layers, wherein at least one of the resin layers is an adsorbing resin layer having a property of adsorbing a conductive substance or a metal. This conductive substance-adsorbing resin film is allowed to adsorb a metal and subjected to plating, whereby a metal layer-coated resin film can be obtained.

  本发明提供了一种导电物质吸附树脂薄膜，在该薄膜上可以很容易地形成导电层，该导电层与树脂薄膜的附着力极佳，并且与树脂薄膜的界面不平整度较低、通过使用本发明的导电物质吸附树脂膜而获得的、可以容易地在其上形成与绝缘树脂膜附着性优良的高清晰配线的金属层涂覆树脂膜，以及作为能够容易地制造具有高清晰配线的印刷线路板的材料的金属层涂覆树脂膜的制造方法。本发明还提供了一种导电物质吸附树脂薄膜，包括至少两个树脂层，其中至少一个树脂层是具有吸附导电物质或金属特性的吸附树脂层。这种导电物质吸附树脂薄膜可以吸附金属并进行电镀，从而获得金属层涂层树脂薄膜。
• Lanthanoids in organic synthesis. 6. Reduction of .alpha.-enones by sodium borohydride in the presence of lanthanoid chlorides: synthetic and mechanistic aspects
  作者：Andre L. Gemal、Jean Louis Luche

  DOI：10.1021/ja00408a029

  日期：1981.9
• PROCESS FOR PRODUCING A METAL FILM COATED MATERIAL, PROCESS FOR PRODUCING A METALLIC PATTERN BEARING MATERIAL AND USE OF A COMPOSITION FOR POLYMER LAYER FORMATION
  申请人：FUJIFILM Corporation

  公开号：EP2078607B1

  公开（公告）日：2018-09-12