2-ethyl-2-hydroxy-1-butanol | 66553-16-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-ethyl-2-hydroxy-1-butanol
• 英文别名: 2-ethyl-1,2-butanediol；2-ethyl-butane-1,2-diol；2-Aethyl-butan-1,2-diol；α.α-Diaethyl-aethylenglykol；(Oxymethyl)-diaethyl-carbinol；3-Methylol-pentanol-(3)；2-Ethylbutane-1,2-diol
• CAS: 66553-16-0
• 化学式: C₆H₁₄O₂
• 分子量: 118.176
• InChiKey: RMEZNLDVMHNLHR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-ethyl-2-hydroxy-1-butanol 在 4-二甲氨基吡啶 、 乙酸酐 、 三乙胺 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 48.0h， 生成 4-Oxo-pentanoic acid 2-ethyl-2-methylsulfanylmethoxy-butyl ester
  参考文献：
  名称：

  Synthesis of diverse ethoxyformacetal oligomers. Toward libraries of metal-coordinating unnatural biopolymers

  摘要：

  An expedient two-step iterative protocol for the solution-phase elaboration of ethoxyformacetal oligomers is described. A set of four O,S-thioformacetal donor monomers, with diverse chiral side-chains, were coupled using NIS/TfOH activation to afford three model tetramers. (C) 1997 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(97)10094-6
• 作为产物：
  描述：

  2-乙基-1-丁烯 在 锇 作用下， 生成 2-ethyl-2-hydroxy-1-butanol
  参考文献：
  名称：

  Synthesis of diverse ethoxyformacetal oligomers. Toward libraries of metal-coordinating unnatural biopolymers

  摘要：

  An expedient two-step iterative protocol for the solution-phase elaboration of ethoxyformacetal oligomers is described. A set of four O,S-thioformacetal donor monomers, with diverse chiral side-chains, were coupled using NIS/TfOH activation to afford three model tetramers. (C) 1997 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(97)10094-6

文献信息

• N-(α-Chloroalkyloxycarbonyl)pyrrolidines as a Source of Oxygenatedd1-Reagents
  作者：Javier Ortiz、Albert Guijarro、Miguel Yus

  DOI：10.1002/(sici)1099-0690(199911)1999:11<3005::aid-ejoc3005>3.0.co;2-7

  日期：1999.11

  Reaction of the N-(α-chloroalkyloxycarbonyl)pyrrolidines 1 with lithium powder and a catalytic amount of 4,4′-di-tert-butylbiphenyl (DTBB, 2.5 mol-%) in the presence of different electrophiles [iBuCHO, tBuCHO, PhCHO, Et2CO, (CH2)5CO, PhCOMe, Ph2CO, Me3SiCl], in THF at temperatures ranging between –78 and –60°C leads, after hydrolysis with water, to the expected functionalized carbamates 2. Deprotection

  所述的反应ñ - （α-chloroalkyloxycarbonyl）吡咯烷1与锂粉末和催化量的4,4'-二-叔-在不同亲电[存在丁基联苯（DTBB，2.5摩尔％）我BuCHO，吨BuCHO ，PhCHO，Et 2 CO，（CH 2）5 CO，PhCOMe，Ph 2 CO，Me 3 SiCl]在THF中在–78至–60°C的温度范围内用水水解后，导致预期的官能化氨基甲酸酯2。化合物的脱保护2由羰基化合物衍生而来，与氢氧化锂在80°C的乙醇和水的混合物中提供相应的1,2-二醇3。
• NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS
  申请人：Carroll William A.

  公开号：US20100069348A1

  公开（公告）日：2010-03-18

  Disclosed herein are cannabinoid receptor ligands of formula (I) wherein A 1 , A 5 , R x , X 4 , and z are as defined in the specification. Compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions are also disclosed.

  本文揭示了公式（I）中的大麻素受体配体，其中A1、A5、Rx、X4和z如规范中定义。还公开了包含这些化合物的组合物，以及使用这些化合物和组合物治疗疾病和疾病的方法。
• N-(Chloromethyloxycarbonyl)pyrrolidine as a source of the HOCH2− synthon
  作者：Albert Guijarro、Miguel Yus

  DOI：10.1016/0040-4039(96)01133-1

  日期：1996.7

  The reaction of N-(chloromethyloxycarbonyl)pyrrolidine (1) with lithium powder and a catalytic amount of DTBB (2.5 mol %) in the presence of different electrophiles [Me3SiCl, BujCHO, ButCHO, PhCHO, Et2CO, (CH2)5CO, PhCOMe, Ph2CO] in THF at −78°C leads, after hydrolysis with water, to the expected functionalised carbamates 2. Deprotection of the acetophenone derivative 2g with DIBALH at THF reflux yields

  的反应Ñ（chloromethyloxycarbonyl）吡咯烷（ - 1在不同的亲电子[我的存在锂粉末和DTBB催化量（2.5摩尔％））3的SiCl，卜Ĵ CHO，卜吨CHO，苯甲醛，等2 CO ，-（CH 2）5 CO，PhCOMe，Ph 2 CO]在THF中于-78°C水解后，可生成预期的官能化氨基甲酸酯2。在THF回流下，用DIBALH对苯乙酮衍生物2g进行脱保护，水解后得到相应的1,2-二醇3g。
• [EN] PROCESS FOR REDUCING THE OXYGEN CONTENT OF BIOMASS USING VANADIUM-BASED CATALYSTS<br/>[FR] PROCÉDÉ POUR RÉDUIRE LA TENEUR EN OXYGÈNE DE LA BIOMASSE À L'AIDE DE CATALYSEURS À BASE DE VANADIUM
  申请人：UNIV DANMARKS TEKNISKE

  公开号：WO2016101958A1

  公开（公告）日：2016-06-30

  The present invention concerns a process for converting biomass into useful organic building blocks for the chemical industry. The process involves the use of vanadium-based catalysts of the formula Aα+a(VvXxR1yR2z)α*a-, which may be readily prepared from industrial vanadium compounds, for converting a polyol in a solvent.

  这项发明涉及将生物质转化为化工行业有用的有机建筑模块的过程。该过程涉及使用具有公式Aα+a(VvXxR1yR2z)α*a-的基于钒的催化剂，这些催化剂可以从工业钒化合物中方便地制备出来，用于将多元醇在溶剂中转化。
• BICYCLIC ENAMINO(THIO)CARBONYL COMPOUNDS
  申请人：Jeschke Peter

  公开号：US20090181947A1

  公开（公告）日：2009-07-16

  The present invention relates to novel bicyclic enamino(thio)carbonyl compounds, to processes for their preparation and to their use for controlling animal pests, especially arthropods, in particular insects.

  本发明涉及新颖的双环烯胺基(硫)酰基化合物，以及其制备方法和用于控制动物害虫，特别是节肢动物，尤其是昆虫的用途。