tert-butylhydrazine oxalate | 32154-73-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: tert-butylhydrazine oxalate
• 英文别名: tert.-Butylhydrazinoxalat；1,1-dimethylethylhydrazine oxalate；tert-butylhydrazine;oxalic acid
• CAS: 32154-73-7
• 化学式: C₂H₂O₄*C₄H₁₂N₂
• 分子量: 178.188
• InChiKey: INHMAQCWZSYJKZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  113
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  tert-butylhydrazine oxalate 在 ammonium hydroxide 、 氢气 、 caesium carbonate 作用下， 以 甲醇 、 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 12.0h， 生成
  参考文献：
  名称：

  [EN] WNT PATHWAY INHIBITOR COMPOUND
  [FR] COMPOSÉ INHIBITEUR DE LA VOIE WNT
  [ZH] 一种Wnt通路抑制剂化合物

  摘要：

  本发明提供了具有优异Wnt通路抑制活性的式(I)结构的化合物或其药学上可接受的盐、同位素衍生物、立体异构体。本发明还提供了所述化合物的制备方法及其用于预防和/或治疗癌症、肿瘤、炎症性疾病、自身免疫性疾病或免疫介导性疾病的用途。

  公开号：

  WO2023143501A1

文献信息

• Preparation of indole containing building blocks for the regiospecific construction of indole appended pyrazoles and pyrroles
  作者：John T. Gupton、Nakul Telang、Dominic F. Gazzo、Peter J. Barelli、Kristin E. Lescalleet、Jonathan W. Fagan、Brandon J. Mills、Kara L. Finzel、Rene P.F. Kanters、Kyle R. Crocker、Sean T. Dudek、Corinne M. Lariviere、Stanton Q. Smith、Kartik M. Keertikar

  DOI：10.1016/j.tet.2013.05.045

  日期：2013.7

  appended vinamidinium salt, an indole appended vinylogous amide and an indole appended chloroenal are described. The subsequent regiospecific conversion of these indole containing building blocks to functionalized pyrazoles and pyrroles is detailed.

  描述了吲哚附加的vinamidinium盐、吲哚附加的乙烯基酰胺和吲哚附加的氯烯醛的制备。详细介绍了这些含有吲哚的结构单元到官能化吡唑和吡咯的后续区域特异性转化。
• Design and synthesis of aminothiazole modulators of the gamma-secretase enzyme
  作者：Kevin D. Rynearson、Ronald N. Buckle、Keith D. Barnes、R. Jason Herr、Nicholas J. Mayhew、William D. Paquette、Samuel A. Sakwa、Phuong D. Nguyen、Graham Johnson、Rudolph E. Tanzi、Steven L. Wagner

  DOI：10.1016/j.bmcl.2016.07.011

  日期：2016.8

  The design and construction of a series of novel aminothiazole-derived gamma-secretase modulators is described. The incorporation of heterocyclic replacements of the terminal phenyl D-ring of lead compound 1 was conducted in order to align potency with favorable drug-like properties. gamma-Secretase modulator 28 displayed good activity for in vitro inhibition of Abeta42, as well as substantial improvement

  描述了一系列新颖的氨基噻唑衍生的γ-分泌酶调节剂的设计和构建。进行铅化合物1的末端苯基D-环的杂环取代基的掺入，以使效力与有利的类药物性质对准。γ-分泌酶调节剂28表现出良好的体外抑制Abeta42活性，以及​​ADME和理化特性（包括水溶性）的显着改善。化合物28在小鼠中的药代动力学评估显示，其良好的大脑渗透能力以及良好的清除率，半衰期和分布体积共同支持了这类化合物的持续开发。
• Anthelmintic N'-substituted-N,N'-disubstitutedhydrazines
  申请人：Rohm and Haas Company

  公开号：US05424333A1

  公开（公告）日：1995-06-13

  This invention relates to the anthelmintic use of compositions containing N'-substituted-N,N'-disubstitutedhydrazines. Specifically, the invention relates to methods of controlling helminths by contacting the helminths with a compound having a nucleus of the formula ##STR1## wherein X and X' are the same or different O, S, or NR and A', B', R.sup.1 and R.sup.2 are a variety of substituents.

  本发明涉及含有N'-取代的N,N'-二取代腙类化合物的驱虫用途。具体来说，本发明涉及通过将具有以下结构式核的化合物与蠕虫接触来控制蠕虫的方法：##STR1##其中X和X'是相同或不同的O、S或NR，A'、B'、R1和R2是各种取代基。
• Insecticidal N' substituted-N-N'-disubstituted-hydrazines
  申请人：Rohm and Haas Company

  公开号：US05117057A1

  公开（公告）日：1992-05-26

  This invention relates to insecticidal compositions containing N'-substituted-N,N'-disubstitutedhydrazines, methods of using such compositions and N'-substituted-N, N'-disubstitutedhydrazines. Specifically, the invention relates to insect growth regulating compositions, and methods of using such compositions, which include compounds having a nucleus of the formula ##STR1## where A', B', D and J are independently any atom or group of atoms; where E is a tertiary carbon containing organic radical, a haloalkyl having a total of at least four carbon and halogen atoms but not more than six halogen atoms, or a non-tertiary carbon containing non-haloalkyl organic or organometallic radical having at least five atoms other than hydrogen, oxygen and halogen, and is attached to the nitrogen shown in the formula by a carbon-to-nitrogen single bond; where one G.sub.1 is C, N, O and S, and both G.sub.2 's and the other G.sub.1 are carbon; or one G.sub.2 is S or P, and both G.sub.1 's and the other G.sub.2 are carbon; where the bonds shown as - - - are independently single or double bonds; where the A'-?-G.sub.1 and G.sub.1 -?-B' bonds are independently single bond, double bonds or aromatic bonds; where organic radical is a radical comprising at least one carbon atom, but no metal atoms; where organometallic radical is a radical containing a carbon-to-metal bond; or an agronomically acceptable salt thereof; and with the provisos discussed infra.

  本发明涉及含有N'-取代-N，N'-二取代腙的杀虫组合物，使用这种组合物和N'-取代-N，N'-二取代腙的方法。具体而言，本发明涉及昆虫生长调节剂组合物及使用这种组合物的方法，其中包括具有以下式子的核的化合物：##STR1## 其中A'，B'，D和J分别是任何原子或原子团；E是含有三级碳的有机基团，是具有至少四个碳和卤素原子总数但不超过六个卤素原子的卤代烷基，或是具有至少五个除氢，氧和卤素之外的原子的非三级碳含量的非卤代烷基有机或有机金属基团，并通过碳-氮单键连接到式中所示的氮；其中一个G.sub.1是C，N，O和S，而两个G.sub.2和另一个G.sub.1是碳；或其中一个G.sub.2是S或P，而两个G.sub.1和另一个G.sub.2是碳；其中所示的- - -键是独立的单键或双键；其中A'-?-G.sub.1和G.sub.1-?-B'键是独立的单键，双键或芳香键；有机基团是至少含有一个碳原子但不含金属原子的基团；有机金属基团是含有碳-金属键的基团；或其农业上可接受的盐；在满足下述条件的情况下。
• Pyrazolospiroketone Acetyl-Coa Carboxylase Inhibitors
  申请人：Freeman-Cook Kevin Daniel

  公开号：US20110009443A1

  公开（公告）日：2011-01-13

  The invention provides compounds of Formula (1) or a pharmaceutically acceptable salt of said compound, wherein R 1 , R 2 , and R 3 are as described herein; pharmaceutical compositions thereof; and the use thereof in treating mammals suffering from the condition of being overweight.

  本发明提供了式（1）的化合物或其药学上可接受的盐，其中R1、R2和R3如本文所述；其制备的药物组合物；以及用于治疗患有超重症的哺乳动物的用途。