N-(2-(furan-2-yl)ethyl)quinolin-2-amine | 1178019-11-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-(2-(furan-2-yl)ethyl)quinolin-2-amine
• 英文别名: N-[2-(furan-2-yl)ethyl]quinolin-2-amine
• CAS: 1178019-11-8
• 化学式: C₁₅H₁₄N₂O
• mdl: MFCD13238608
• 分子量: 238.289
• InChiKey: GABOGBQPOBHYMA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.133
• 拓扑面积：
  38.1
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-氨基乙基呋喃 、 2-氯喹啉 在 Brettphos palladacycle 、 lithium hexamethyldisilazane 、 2-二环己基磷-2',6'-二异丙氧基-1,1'-联苯 作用下， 以 四氢呋喃 为溶剂， 反应 24.0h， 以97%的产率得到N-(2-(furan-2-yl)ethyl)quinolin-2-amine
  参考文献：
  名称：

  A Multiligand Based Pd Catalyst for C−N Cross-Coupling Reactions

  摘要：

  An alternative approach to catalyst development, which led to a Pd catalyst based on two biarylphosphine ligands for C-N cross-coupling reactions, is reported. By effectively being able to take the form of multiple catalysts this system manifests the best properties that catalysts based on either of the two ligands exhibit separately and displays the highest reactivity and substrate scope of any system that has been reported to date for these reactions.

  DOI：

  10.1021/ja108074t

文献信息

• A Multiligand Based Pd Catalyst for C−N Cross-Coupling Reactions
  作者：Brett P. Fors、Stephen L. Buchwald

  DOI：10.1021/ja108074t

  日期：2010.11.17

  An alternative approach to catalyst development, which led to a Pd catalyst based on two biarylphosphine ligands for C-N cross-coupling reactions, is reported. By effectively being able to take the form of multiple catalysts this system manifests the best properties that catalysts based on either of the two ligands exhibit separately and displays the highest reactivity and substrate scope of any system that has been reported to date for these reactions.