(1R,2S,3R)-3-isopropyl-1-methyl-2-((3S)-3-methylpent-4-enyl)-1-(2-oxoethyl)cyclopentane | 1048342-08-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (1R,2S,3R)-3-isopropyl-1-methyl-2-((3S)-3-methylpent-4-enyl)-1-(2-oxoethyl)cyclopentane
• CAS: 1048342-08-0
• 化学式: C₁₇H₃₀O
• 分子量: 250.425
• InChiKey: CKILOHXRRDSRHZ-WCXIOVBPSA-N

反应信息

• 作为反应物：
  描述：

  (1R,2S,3R)-3-isopropyl-1-methyl-2-((3S)-3-methylpent-4-enyl)-1-(2-oxoethyl)cyclopentane 、 (1-重氮基-2-氧代丙基)膦酸二甲酯 在 potassium carbonate 作用下， 以 甲醇 为溶剂， 反应 12.0h， 以85%的产率得到(1R,2S,3R)-3-isopropyl-1-methyl-2-((3S)-3-methylpent-4-enyl)-1-(prop-2-ynyl)cyclopentane
  参考文献：
  名称：

  A Synthetic Approach to the Fusicoccane A−B Ring Fragment Based on a Pauson−Khand Cycloaddition/Norrish Type 1 Fragmentation

  摘要：

  A synthetic approach to the A-B ring system within the fusicoccane family of diterpenes is presented. Key steps in this approach are a diastereoselective Pauson-Khand reaction, a Norrish 1 photofragmentation, a Charette cyclopropanation, and a ring-closing metathesis process.

  DOI：

  10.1021/jo800933f
• 作为产物：
  描述：

  (1R,2S,3R)-3-isopropyl-1-((2S)-2,3-O-isopropylidene-2,3-dihydroxypropyl)-1-methyl-2-((3S)-3-methylpent-4-enyl)cyclopentane 在 过碘酸 作用下， 以 乙酸乙酯 为溶剂， 反应 3.0h， 以85%的产率得到(1R,2S,3R)-3-isopropyl-1-methyl-2-((3S)-3-methylpent-4-enyl)-1-(2-oxoethyl)cyclopentane
  参考文献：
  名称：

  A Synthetic Approach to the Fusicoccane A−B Ring Fragment Based on a Pauson−Khand Cycloaddition/Norrish Type 1 Fragmentation

  摘要：

  A synthetic approach to the A-B ring system within the fusicoccane family of diterpenes is presented. Key steps in this approach are a diastereoselective Pauson-Khand reaction, a Norrish 1 photofragmentation, a Charette cyclopropanation, and a ring-closing metathesis process.

  DOI：

  10.1021/jo800933f