Troc-(S)-Thr-(S)-Phe-OAllyl | 370867-47-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Troc-(S)-Thr-(S)-Phe-OAllyl
• 英文别名: Troc-(S)-Thr-Phe-OAlly；prop-2-enyl (2S)-2-[[(2S,3R)-3-hydroxy-2-(2,2,2-trichloroethoxycarbonylamino)butanoyl]amino]-3-phenylpropanoate
• CAS: 370867-47-3
• 化学式: C₁₉H₂₃Cl₃N₂O₆
• 分子量: 481.76
• InChiKey: MZIOIIUGDQQMDP-SNPRPXQTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  30
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  114
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  Troc-(S)-Thr-(S)-Phe-OAllyl 在 palladium dihydroxide 、 四(三苯基膦)钯 吗啉 、 咪唑 、 盐酸 、 4-二甲氨基吡啶 、 氰基磷酸二乙酯 、 五氟苯基二苯基磷酸酯 、 氢气 、 溶剂黄146 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 三乙胺 、 N,N-二异丙基乙胺 、 锌 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 二氯甲烷 、 乙酸乙酯 、 N,N-二甲基甲酰胺 为溶剂， 20.0 ℃ 、101.33 kPa 条件下， 反应 98.5h， 生成 dibenzyl [(2S)-2-[tert-butyl(dimethyl)silyl]oxy-3-[[(3S,6S,9S,12S,15S,18S,19R)-9,15-dibenzyl-3-[(2S)-butan-2-yl]-6-[[4-[tert-butyl(dimethyl)silyl]oxyphenyl]methyl]-12-(3-hydroxypropyl)-7,19-dimethyl-2,5,8,11,14,17-hexaoxo-1-oxa-4,7,10,13,16-pentazacyclononadec-18-yl]amino]-3-oxopropyl] phosphate
  参考文献：
  名称：

  Synthetic studies of the cyclic depsipeptides bearing the 3-amino-6-hydroxy-2-piperidone (Ahp) unit. Total synthesis of the proposed structure of micropeptin T-20

  摘要：

  The first total synthesis of a cyclic depsipeptide possessing the 3-amino-6-hydroxy-2-piperidone (Ahp) unit was successfully IN achieved in a convergent manner by the oxidative construction of the Ahp unit at the later stage of the synthesis. This synthetic work provides data indicating that the structure of the target Ahp-depsipeptide, micropeptin T-20. should be re-examined. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2004.12.009
• 作为产物：
  描述：

  2-tert-butoxycarbonylamino-3-phenylpropionic acid allyl ester 在 盐酸 、 氰基磷酸二乙酯 、 三乙胺 作用下， 以 乙酸乙酯 、 N,N-二甲基甲酰胺 为溶剂， 反应 21.5h， 生成 Troc-(S)-Thr-(S)-Phe-OAllyl
  参考文献：
  名称：

  Synthetic studies of the cyclic depsipeptides bearing the 3-amino-6-hydroxy-2-piperidone (Ahp) unit. Total synthesis of the proposed structure of micropeptin T-20

  摘要：

  The first total synthesis of a cyclic depsipeptide possessing the 3-amino-6-hydroxy-2-piperidone (Ahp) unit was successfully IN achieved in a convergent manner by the oxidative construction of the Ahp unit at the later stage of the synthesis. This synthetic work provides data indicating that the structure of the target Ahp-depsipeptide, micropeptin T-20. should be re-examined. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2004.12.009

文献信息

• Synthetic studies of micropeptin T-20, a novel 3-amino-6-hydroxy-2-piperidone (Ahp)-containing cyclic depsipeptide
  作者：Fumiaki Yokokawa、Akiko Inaizumi、Takayuki Shioiri

  DOI：10.1016/s0040-4039(01)01136-4

  日期：2001.8

  The synthetic studies of micropeptin T-20 including the late installation of the Ahp (3 -amino- 6-hydroxy-2-piperidone) residue through oxidation and cyclization of a homoserine to the requisite hemiaminal are described. (C) 2001 Elsevier Science Ltd. All rights reserved.
• Synthetic studies of the cyclic depsipeptides bearing the 3-amino-6-hydroxy-2-piperidone (Ahp) unit. Total synthesis of the proposed structure of micropeptin T-20
  作者：Fumiaki Yokokawa、Akiko Inaizumi、Takayuki Shioiri

  DOI：10.1016/j.tet.2004.12.009

  日期：2005.2

  The first total synthesis of a cyclic depsipeptide possessing the 3-amino-6-hydroxy-2-piperidone (Ahp) unit was successfully IN achieved in a convergent manner by the oxidative construction of the Ahp unit at the later stage of the synthesis. This synthetic work provides data indicating that the structure of the target Ahp-depsipeptide, micropeptin T-20. should be re-examined. (C) 2004 Elsevier Ltd. All rights reserved.