4-羟基-6,7-二氯喹啉 | 203626-51-1

• 物质功能分类: 医药中间体 - 喹啉类化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 4-羟基-6,7-二氯喹啉
• 英文名称: 6,7-Dichloro-quinolin-4-ol
• 英文别名: 4-Hydroxy-6,7-dichloroquinoline；6,7-dichloro-1H-quinolin-4-one
• CAS: 203626-51-1
• 化学式: C₉H₅Cl₂NO
• mdl: MFCD00272452
• 分子量: 214.051
• InChiKey: OIBDGJOVXZXMSP-UHFFFAOYSA-N

物化性质

• 沸点：
  383.6±37.0 °C(Predicted)
• 密度：
  1.538±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-羟基-6,7-二氯喹啉 在 三氯氧磷 作用下， 反应 3.0h， 生成 4-氯-6,7-二氯喹啉
  参考文献：
  名称：

  Synthesis of ring-substituted 4-aminoquinolines and evaluation of their antimalarial activities

  摘要：

  A simple two-step synthesis method was used to make 51 B-ring-substituted 4-hydroxyquinolines allowing analysis of the effect of ring substitutions on inhibition of growth of chloroquine sensitive and resistant strains of Plasmodium falciparum, the dominant cause of malaria morbidity. Substituted quinoline rings other than the 7-chloroquinoline ring found in chloroquine were found to have significant activity against the drug-resistant strain of P. falciparum W2. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.12.037
• 作为产物：
  描述：

  5-[(3,4-Dichloroanilino)methylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione 以 二苯醚 为溶剂， 反应 0.08h， 生成 5,6-Dichloro-quinolin-4-ol 、 4-羟基-6,7-二氯喹啉
  参考文献：
  名称：

  Synthesis of ring-substituted 4-aminoquinolines and evaluation of their antimalarial activities

  摘要：

  A simple two-step synthesis method was used to make 51 B-ring-substituted 4-hydroxyquinolines allowing analysis of the effect of ring substitutions on inhibition of growth of chloroquine sensitive and resistant strains of Plasmodium falciparum, the dominant cause of malaria morbidity. Substituted quinoline rings other than the 7-chloroquinoline ring found in chloroquine were found to have significant activity against the drug-resistant strain of P. falciparum W2. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.12.037

文献信息

• [EN] PAPD5 INHIBITORS AND METHODS OF USE THEREOF<br/>[FR] INHIBITEURS DE PAPD5 ET LEURS PROCÉDÉS D'UTILISATION
  申请人：CHILDRENS MEDICAL CT CORP

  公开号：WO2023086220A2

  公开（公告）日：2023-05-19

  The present application provides compounds that are PAPD5 inhibitors and are useful in treating a variety of conditions such as cancer, telomere diseases, viral infections, and aging-related and other degenerative disorders.

  本申请提供的化合物是 PAPD5 抑制剂，可用于治疗多种疾病，如癌症、端粒疾病、病毒感染、衰老相关疾病和其他退行性疾病。