ethyl 2-(7-chloro-5,8-dioxo-5,8-dihydroquinolin-6-yl)-2-cyanoacetate | 134145-55-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: ethyl 2-(7-chloro-5,8-dioxo-5,8-dihydroquinolin-6-yl)-2-cyanoacetate
• 英文别名: ethyl 2-(7-chloro-5,8-dioxoquinolin-6-yl)-2-cyanoacetate
• CAS: 134145-55-4
• 化学式: C₁₄H₉ClN₂O₄
• 分子量: 304.689
• InChiKey: RTNOCKIYQLOUNU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.66
• 重原子数：
  21.0
• 可旋转键数：
  3.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  97.12
• 氢给体数：
  0.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  ethyl 2-(7-chloro-5,8-dioxo-5,8-dihydroquinolin-6-yl)-2-cyanoacetate 在 三正丁胺 作用下， 以 乙醇 为溶剂， 以65%的产率得到2-ethoxy-4,9-dioxofuro[3,2-g]quinoline-3-carbonitrile
  参考文献：
  名称：

  Yanni; Khalil, Journal of the Indian Chemical Society, 1990, vol. 67, # 9, p. 777 - 779

  摘要：

  DOI：
• 作为产物：
  描述：

  6,7-二氯-5,8-喹啉二酮 、 氰乙酸乙酯 在 ammonium hydroxide 作用下， 以 乙醇 为溶剂， 反应 0.17h， 生成 ethyl 2-(7-chloro-5,8-dioxo-5,8-dihydroquinolin-6-yl)-2-cyanoacetate
  参考文献：
  名称：

  Synthesis and antifungal activity of 1H-pyrrolo[3,2-g]quinoline-4,9-diones and 4,9-dioxo-4,9-dihydro-1H-benzo[f]indoles

  摘要：

  1H-Pyrrolo[3,2-g]quinoline-4,9-diones and 4,9-dioxo-4,9-dihydro-1H-benzo[f]indoles were synthesized and tested for in vitro antifungal activity against fungi. Among them tested, many compounds showed good antifungal activity. The results suggest that 1H-pyrrolo[3,2-g]quinoline-4,9-diones and 4,9-dioxo-4,9-dihydro-1H-benzo[f]indoles would be potent antifungal agents. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.10.131

文献信息

• Yanni, Amal S.; Khalil, Zarif H., Collection of Czechoslovak Chemical Communications, 1991, vol. 56, # 3, p. 706 - 711
  作者：Yanni, Amal S.、Khalil, Zarif H.

  DOI：——

  日期：——
• Synthesis and antifungal activity of furo[2,3-f]quinolin-5-ols
  作者：Chung-Kyu Ryu、Yang Hui Kim、Ji-Hee Nho、Jung An Hong、Joo Hee Yoon、Aram Kim

  DOI：10.1016/j.bmcl.2010.12.058

  日期：2011.2

  Furo[2,3-f]quinolin-5-ol derivatives were synthesized and tested for in vitro antifungal activity against Candida, Aspergillus species, and Cryptococcus neoformans. Among them tested, many furo[2,3-f]quinolin-5-ols showed good antifungal activity. The results suggest that furo[2,3-f]quinolin-5-ols would be promising antifungal agents. (C) 2010 Elsevier Ltd. All rights reserved.
• YANNI, AMAL S.;KHALIL, ZARIF H., J. INDIAN CHEM. SOC., 67,(1990) N, C. 777-779
  作者：YANNI, AMAL S.、KHALIL, ZARIF H.

  DOI：——

  日期：——
• YANNI, AMAL S.;KHALIL, ZARIF H., COLLECT. CZECHOSL. CHEM. COMMUN., 56,(1991) N, C. 706-711
  作者：YANNI, AMAL S.、KHALIL, ZARIF H.

  DOI：——

  日期：——