4-fluoro-4-nitro-5-phenyl-1-(p-tolyl)pentan-1-one | 1423065-65-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-fluoro-4-nitro-5-phenyl-1-(p-tolyl)pentan-1-one
• 英文别名: 4-Fluoro-1-(4-methylphenyl)-4-nitro-5-phenylpentan-1-one；4-fluoro-1-(4-methylphenyl)-4-nitro-5-phenylpentan-1-one
• CAS: 1423065-65-9
• 化学式: C₁₈H₁₈FNO₃
• 分子量: 315.344
• InChiKey: FHOPHWBIJFGRQE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  62.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-(4-甲基苯基)丙-2-烯-1-酮 、 (2-氟-2-硝基乙基)苯 在 [RuH2(PPh3)4] 作用下， 以 乙腈 为溶剂， 反应 22.0h， 以51%的产率得到4-fluoro-4-nitro-5-phenyl-1-(p-tolyl)pentan-1-one
  参考文献：
  名称：

  [RuH2(PPh3)4]-Catalyzed Michael Addition Reaction of α-Fluoronitroalkanes

  摘要：

  The Michael addition reactions of alpha-fluoronitroalkanes with various electron-deficient olefins were realized by catalysis of low-valence ruthenium species through C-sp3-H activation, providing a useful way to construct a fluorinated quaternary carbon center. The reactions were carried out under neutral conditions, affording the desired products in moderate to excellent yields.

  DOI：

  10.1055/s-0032-1317526

文献信息

• [RuH2(PPh3)4]-Catalyzed Michael Addition Reaction of α-Fluoronitroalkanes
  作者：Xianjin Yang、Yong Guo、Qi Wang、Qing-Yun Chen

  DOI：10.1055/s-0032-1317526

  日期：——

  The Michael addition reactions of alpha-fluoronitroalkanes with various electron-deficient olefins were realized by catalysis of low-valence ruthenium species through C-sp3-H activation, providing a useful way to construct a fluorinated quaternary carbon center. The reactions were carried out under neutral conditions, affording the desired products in moderate to excellent yields.