(1-mercaptoundec-11-yl)tetra(ethylene glycol) | 130727-42-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (1-mercaptoundec-11-yl)tetra(ethylene glycol)
• 英文别名: 23-Sulfanyl-3,6,9,12-tetraoxatricosan-1-OL；2-[2-[2-[2-(11-sulfanylundecoxy)ethoxy]ethoxy]ethoxy]ethanol
• CAS: 130727-42-3
• 化学式: C₁₉H₄₀O₅S
• 分子量: 380.59
• InChiKey: IOBMVUDHPRVCSO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  25
• 可旋转键数：
  22
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (1-mercaptoundec-11-yl)tetra(ethylene glycol) 在 potassium carbonate 、 copper(II) sulfate 作用下， 以 1,4-二氧六环 为溶剂， 生成 2-[2-[2-[2-[11-[11-[2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]ethoxy]undecyldisulfanyl]undecoxy]ethoxy]ethoxy]ethoxy]ethanol
  参考文献：
  名称：

  On-Demand Electrochemical Activation of the Click Reaction on Self-Assembled Monolayers on Gold Presenting Masked Acetylene Groups

  摘要：

  We report on a new surface modification method for grafting a "dynamic" property for on-demand activation of the click reaction. Our approach utilizes the acetylene group masked with dicobalt hexacarbonyl, Co-2-(CO)(6), which is not reactive toward the click reaction. Electrochemical treatment reveals the acetylene group on the selected region, which is then used as a chemical handle for surface functionalization via the click reaction with an azide-containing molecule. Electrochemical and chemical conversions on the surface were verified by cyclic voltammetry, X-ray photoelectron spectroscopy, and fluorescence spectroscopy. We have demonstrated immobilization of an azide-modified RGD peptide and promotion of cell adhesion/migration to the region of electrochemical induction.

  DOI：

  10.1021/ja2083587
• 作为产物：
  描述：

  11-溴-1-十一醇 在 三异丙基硅烷 、 三乙胺 、 三氟乙酸 、 sodium hydroxide 作用下， 以 乙醇 、 二氯甲烷 、 水 、 甲苯 为溶剂， 反应 48.0h， 生成 (1-mercaptoundec-11-yl)tetra(ethylene glycol)
  参考文献：
  名称：

  快速而简单地制备非常稳定的二元纳米粒子行星-卫星组件

  摘要：

  我们展示了一种简单的非生物分子方法，用于二元NP行星卫星超结构的自组装，该结构在温度，pH，离子强度和溶剂的变化下显示出显着的胶体和结构稳定性。这...

  DOI：

  10.1039/c5cc01543j

文献信息

• Ligand Conjugation of Chemically Exfoliated MoS₂
  作者：Stanley S. Chou、Mrinmoy De、Jaemyung Kim、Segi Byun、Conner Dykstra、Jin Yu、Jiaxing Huang、Vinayak P. Dravid

  DOI：10.1021/ja310929s

  日期：2013.3.27

  MoS2 is a two-dimensional material that is gaining prominence due to its unique electronic and chemical properties. Here, we demonstrate ligand conjugation of chemically exfoliated MoS2 using thiol chemistry. With this method, we modulate the ζ-potential and colloidal stability of MoS2 sheets through ligand designs, thus enabling its usage as a selective artificial protein receptor for β-galactosidase

  MoS2 是一种二维材料，由于其独特的电子和化学性质而越来越受到重视。在这里，我们使用硫醇化学证明了化学剥离的 MoS2 的配体共轭。使用这种方法，我们通过配体设计调节 MoS2 片层的 ζ 电位和胶体稳定性，从而使其能够用作 β-半乳糖苷酶的选择性人工蛋白质受体。简便的硫醇官能化路线为可溶液加工的 MoS2 片材的表面改性打开了大门。
• SUGAR CHAIN CONTAINING 4-POSITION HALOGENATED GALACTOSE AND APPLICATION THEREOF
  申请人：Nishimura Shin-Ichiro

  公开号：US20090018327A1

  公开（公告）日：2009-01-15

  The present invention is directed to, for example, an oligosaccharide having at an end thereof a 4-position halogenated galactose residue represented by formula (I): (wherein X represents a halogen atom, and R represents a monosaccharide, an oligosaccharide, or a carrier), a transferase inhibitor containing the oligosaccharide, and a method for inhibiting sugar chain elongation reaction in the presence of glycosyltransferase, the method including employing the inhibitor. The invention also provides a method for producing a 4-position halogenated galactose sugar nucleotide represented by formula (II): (wherein each of R 1 to R 3 represents a hydroxyl group, an acetyl group, a halogen atom, or a hydrogen atom; X represents a halogen atom; and M represents a hydrogen ion or a metal ion), wherein the method employs bacterium-derived galactokinase and bacterium-derived hexose-1-phosphate uridylyltransferase. The invention is also directed to a sugar chain containing 4-position halogenated galactose envisaged to be employed as drugs and other materials, and to applications of the compound.

  本发明涉及一种寡糖，其末端具有由公式(I)表示的4位卤代半乳糖残基：（其中X代表卤素原子，R代表单糖，寡糖或载体），含有该寡糖的转移酶抑制剂，以及在存在糖基转移酶时抑制糖链延长反应的方法，该方法包括使用该抑制剂。该发明还提供了一种生产由公式(II)表示的4位卤代半乳糖核苷酸的方法：（其中R1至R3中的每一个代表羟基、乙酰基、卤素原子或氢原子；X代表卤素原子；M代表氢离子或金属离子），该方法利用细菌来源的半乳糖激酶和细菌来源的己糖-1-磷酸尿苷转移酶。本发明还涉及一种含有4位卤代半乳糖的糖链，可用作药物和其他材料，并涉及该化合物的应用。
• Multiplexed Screening of Cellular Uptake of Gold Nanoparticles Using Laser Desorption/Ionization Mass Spectrometry
  作者：Zheng-Jiang Zhu、Partha S. Ghosh、Oscar R. Miranda、Richard W. Vachet、Vincent M. Rotello

  DOI：10.1021/ja805392f

  日期：2008.10.29

  Gold nanoparticles (AuNPs) are highly promising candidates as drug delivery agents into cells of interest. We describe for the first time the multiplexed analysis of nanoparticle uptake by cells using mass spectrometry. We demonstrate that the cellular uptake of functionalized gold nanoparticles with cationic or neutral surface ligands can be readily determined using laser desorption/ionization mass

  金纳米粒子 (AuNPs) 是非常有前途的候选药物，可将药物递送到感兴趣的细胞中。我们首次描述了使用质谱法对细胞对纳米颗粒摄取的多重分析。我们证明使用细胞裂解物的激光解吸/电离质谱法可以很容易地确定具有阳离子或中性表面配体的功能化金纳米粒子的细胞摄取。表面配体具有“质量条码”，允许在低至 30 pmol 的水平下同时识别和量化不同的纳米粒子。使用这种方法，我们发现 AuNP 表面功能的细微变化会导致细胞摄取倾向的可测量变化。
• [EN] COATING FOR METAL NANOPARTICLES<br/>[FR] REVÊTEMENT POUR NANOPARTICULES MÉTALLIQUES
  申请人：AGENCY SCIENCE TECH & RES

  公开号：WO2017058113A1

  公开（公告）日：2017-04-06

  The invention relates to a ligand compound having a structure A-B-C, wherein (a) A represents a mono- or polyphosphorylated amino acid linked to part B by its amino group to form an amide bond; B represents (i) a carboxylic acid, and (ii) an amino acid or peptidyl group of 2-10 amino acids, an alkyl or alkenyl group comprising 1 -26 carbon atoms, a polyethylene glycol group comprising 1 -26 carbon atoms or a combination thereof covalently linked to the carboxylic acid; and C represents a hydrophilic group covalently linked to the group of B (ii) or (b) A represents a mono-or polyphosphorylated amino acid linked to B by its carboxylic acid to form an amide bond; B represents an amino acid or peptidyl group of 2-10 amino acids, an amino substituted alkyl or alkenyl group comprising 1 -26 carbon atoms, an amino substituted polyethylene glycol group comprising 1 -26 carbon atoms or a combination thereof covalently linked to A by their amino group; C represents a hydrophilic group covalently linked to the group of B. The invention further relates to a coated metal nanoparticle such as super paramagnetic iron oxide nanoparticle (SPIONs) coated with a plurality of the aforementioned ligands and a method of producing thereof.

  本发明涉及一种具有A-B-C结构的配体化合物，其中（a）A代表一种单磷酸化或多磷酸化的氨基酸，通过其氨基与部分B形成酰胺键相连；B代表（i）一种羧酸，以及（ii）一种由2-10个氨基酸、1-26个碳原子的烷基或烯基，1-26个碳原子的聚乙二醇基或它们的组合物与羧酸共价结合的氨基酸或肽基团；C代表与B（ii）的基团共价结合的亲水基团；或（b）A代表一种单磷酸化或多磷酸化的氨基酸，通过其羧酸与B形成酰胺键相连；B代表由2-10个氨基酸、1-26个碳原子的氨基取代的烷基或烯基，1-26个碳原子的氨基取代的聚乙二醇基或它们的组合物通过其氨基与A共价结合的氨基酸或肽基团；C代表与B的基团共价结合的亲水基团。本发明还涉及一种被多个上述配体包覆的金属纳米粒子，如超顺磁性氧化铁纳米粒子（SPIONs），以及其制备方法。
• [EN] NEAR-INFRARED FLUOROGENIC PORPHYCENE DERIVATIVES AS FLUORESCENT LABELS FOR PHOTODIAGNOSIS AND PHOTOTHERAPEUTIC USE<br/>[FR] DÉRIVÉS DE PORPHYCÈNE FLUOROGÈNES PROCHE INFRAROUGE EN TANT QUE MARQUEURS FLUORESCENTS POUR LE PHOTODIAGNOSTIC ET UTILISATION EN PHOTOTHÉRAPIE
  申请人：INST QUÍMIC DE SARRIÁ CETS FUNDACIÓ PRIVADA

  公开号：WO2015197510A1

  公开（公告）日：2015-12-30

  The present invention relates to isothiocyanate substituted porphycenes, to their preparation, to their use for labelling biomolecules, nanoparticles, polymers and solid supports, formation of heteroaryl-fused porphycene porphycenes, pharmaceutical compositions thereof and their use in medicine, in particular, in photodynamic therapy.

  本发明涉及异硫氰基取代的卟啉烯，其制备方法，用于标记生物分子、纳米粒子、聚合物和固体支持材料的用途，异杂芳基融合的卟啉烯卟啉烯的形成，其制药组合物及其在医学中的应用，特别是在光动力疗法中的应用。