N-2-(2"-N'-methylanthraniloylaminoethyl)guanosine | 221277-21-0

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: N-2-(2"-N'-methylanthraniloylaminoethyl)guanosine
• 英文别名: N-[2-[[9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-oxo-1H-purin-2-yl]amino]ethyl]-2-(methylamino)benzamide
• CAS: 221277-21-0
• 化学式: C₂₀H₂₅N₇O₆
• 分子量: 459.462
• InChiKey: BLINIBICERPAIU-QEPJRFBGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  33
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  182
• 氢给体数：
  7
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  N-2-(2"-N'-methylanthraniloylaminoethyl)guanosine 在 磷酸三甲酯 、 三正丁胺 、 tri-n-butylammonium salt of imidodiphosphate 、 三氯氧磷 作用下， 生成 N-2-(2"-N'-methylanthraniloylaminoethyl)guanosine-5'-(β,γ-imido)triphosphate
  参考文献：
  名称：

  New N-2-Labelled Fluorescent Derivatives of Guanosine Nucleotides and Their Interaction with GTP-Binding Proteins

  摘要：

  Convenient syntheses of new fluorescent derivatives of guanosine nucleotides are described. The analogs bear a fluorescent group attached by an aliphatic linker containing 2 or 4 methylene groups on the N-2 position of the guanine base. They interact with the small GTPases H-Ras and cdc42 with an accompanying increase in fluorescence yield and display kinetic constants which are similar to those of unmodified nucleotides. The derivatives thus appear to be attractive alternatives to the widely used 2'(3')-O-methylanthraniloyl derivatives and are likely to be useful for GTPases which do not tolerate modifications of the sugar moiety of the nucleoside.

  DOI：

  10.1080/15257779908043072
• 作为产物：
  描述：

  sodium salt of inosine-2-sulfonate 在 sodium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 7.0h， 生成 N-2-(2"-N'-methylanthraniloylaminoethyl)guanosine
  参考文献：
  名称：

  New N-2-Labelled Fluorescent Derivatives of Guanosine Nucleotides and Their Interaction with GTP-Binding Proteins

  摘要：

  Convenient syntheses of new fluorescent derivatives of guanosine nucleotides are described. The analogs bear a fluorescent group attached by an aliphatic linker containing 2 or 4 methylene groups on the N-2 position of the guanine base. They interact with the small GTPases H-Ras and cdc42 with an accompanying increase in fluorescence yield and display kinetic constants which are similar to those of unmodified nucleotides. The derivatives thus appear to be attractive alternatives to the widely used 2'(3')-O-methylanthraniloyl derivatives and are likely to be useful for GTPases which do not tolerate modifications of the sugar moiety of the nucleoside.

  DOI：

  10.1080/15257779908043072