xanthoangelol H | 265652-89-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: xanthoangelol H
• 英文别名: (E)-1-(3-hydroxy-5-methoxy-2,2-dimethyl-3,4-dihydrochromen-8-yl)-3-(4-hydroxyphenyl)prop-2-en-1-one
• CAS: 265652-89-9
• 化学式: C₂₁H₂₂O₅
• 分子量: 354.403
• InChiKey: BLZMHRPUJFCGIJ-UXBLZVDNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  76
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  在 对甲苯磺酸 作用下， 以 甲醇 为溶剂， 反应 2.0h， 以94%的产率得到xanthoangelol H
  参考文献：
  名称：

  Synthesis of 4-hydroxyderricin and related derivatives

  摘要：

  Naturally occurring chalcones, namely 4-hydroxyderricin (1), xanthoangelol H (2), deoxyxanthoangelol H (3). and deoxydihydroxanthoangelol H (4), were first synthesized and evaluated for antibacterial activities. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.09.015

文献信息

• Therapeutic agent
  申请人：Enoki Tatsuji

  公开号：US20070092551A1

  公开（公告）日：2007-04-26

  A therapeutic agent and prophylactic agent for a disease accompanying an abnormality in an amount of insulin or insulin response, an agent for an insulin-mimetic action, a food, beverage and feed, an agent for enhancing glucose uptake into a cell, and an agent for inducing differentiation into an adipocyte, characterized in that each comprises as an effective ingredient at least one compound selected from the group consisting of a chalcone compound, an acetophenone compound, a coumarin compound, a phthalide compound, derivatives thereof, and pharmacologically acceptable salts thereof.

  一种治疗伴随胰岛素或胰岛素反应异常的疾病的治疗剂和预防剂，一种具有类胰岛素作用的剂，一种食品、饮料和饲料，一种增强葡萄糖进入细胞的剂，以及一种诱导分化成脂肪细胞的剂，其特征在于每种剂都包含至少一种有效成分，所述有效成分选自香豆素类化合物、苯乙酮类化合物、香豆酮类化合物、邻苯二甲酸酯类化合物及其衍生物和药学上可接受的盐。
• REMEDIES
  申请人：TAKARA BIO INC.

  公开号：EP1386919A1

  公开（公告）日：2004-02-04

  The present invention relates to a medicament, a food, a beverage or a feed, each comprising as an effective ingredient a compound having an enhancing action for NGF production, which is effective for a treatment, an amelioration of symptom, prevention or the like of a disease requiring enhancement of NGF production, wherein the compound has a coumarin and/or chroman backbone. Since no toxicity is especially found in the effective ingredient of the present invention, and there is no risk of incidence of adverse actions, the treatment or the like of the above disease can be safely and appropriately carried out.

  本发明涉及一种药物、一种食品、一种饮料或一种饲料，每种药物、食品、饮料或饲料的有效成分都包含一种具有促进NGF生成作用的化合物，该化合物对治疗、改善症状、预防或类似需要促进NGF生成的疾病有效，其中该化合物具有香豆素和/或铬烷骨架。由于本发明的有效成分没有毒性，也没有发生不良反应的风险，因此可以安全、适当地治疗上述疾病。
• Remedies
  申请人：——

  公开号：US20040122082A1

  公开（公告）日：2004-06-24

  The present invention relates to a medicament, a food, a beverage or a feed, each comprising as an effective ingredient a compound having an enhancing action for NGF production, which is effective for a treatment, an amelioration of symptom, prevention or the like of a disease requiring enhancement of NGF production, wherein the compound has a coumarin and/or chroman backbone. Since no toxicity is especially found in the effective ingredient of the present invention, and there is no risk of incidence of adverse actions, the treatment or the like of the above disease can be safely and appropriately carried out.

  本发明涉及一种药物、一种食品、一种饮料或一种饲料，每种药物、食品、饮料或饲料的有效成分都包含一种具有促进NGF生成作用的化合物，该化合物对治疗、改善症状、预防或类似需要促进NGF生成的疾病有效，其中该化合物具有香豆素和/或铬烷骨架。由于本发明的有效成分没有毒性，也没有发生不良反应的风险，因此可以安全、适当地治疗上述疾病。
• US7078386B2
  申请人：——

  公开号：US7078386B2

  公开（公告）日：2006-07-18
• Synthesis of 4-hydroxyderricin and related derivatives
  作者：Kazuhiro Sugamoto、Chiaki Kurogi、Yoh-ichi Matsushita、Takanao Matsui

  DOI：10.1016/j.tetlet.2008.09.015

  日期：2008.11

  Naturally occurring chalcones, namely 4-hydroxyderricin (1), xanthoangelol H (2), deoxyxanthoangelol H (3). and deoxydihydroxanthoangelol H (4), were first synthesized and evaluated for antibacterial activities. (C) 2008 Elsevier Ltd. All rights reserved.