N-[2-(3,4-bis-benzyloxyphenyl)ethyl]succinimic acid 2,5-dioxo-pyrrolidin-1-yl ester | 760190-09-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: N-[2-(3,4-bis-benzyloxyphenyl)ethyl]succinimic acid 2,5-dioxo-pyrrolidin-1-yl ester
• CAS: 760190-09-8
• 化学式: C₃₀H₃₀N₂O₇
• 分子量: 530.577
• InChiKey: AZDKMFJDCGGHNP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.89
• 重原子数：
  39.0
• 可旋转键数：
  13.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  111.24
• 氢给体数：
  1.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  N-[2-(3,4-bis-benzyloxyphenyl)ethyl]succinimic acid 2,5-dioxo-pyrrolidin-1-yl ester 在 palladium on activated charcoal 、 氢气 、 碳酸氢钠 作用下， 以 甲醇 、 乙醇 、 氯仿 为溶剂， 反应 48.0h， 生成 2-(bis-carboxymethylamino)-6-{3-[2-(3,4-dihydroxyphenyl)ethylcarbamoyl]propionylamino}hexanoic acid
  参考文献：
  名称：

  Dopamine as A Robust Anchor to Immobilize Functional Molecules on the Iron Oxide Shell of Magnetic Nanoparticles

  摘要：

  We report on the use of dopamine (DA) as a robust molecular anchor to link functional molecules to the iron oxide shell of magnetic nanoparticles. Using nitrilotriacetic acid (NTA) as the functional molecule, we created a system with an M/Fe2O3-DA-NTA (M = Co or SmCo5.2) nanostructure, which possesses high stability and specificity for separating histidine-tagged proteins. The well-established biocompatibility of iron oxide and the robust covalent bonds between DA and Fe2O3 render this strategy attractive for constructing biofunctional magnetic nanoparticles containing iron oxide.

  DOI：

  10.1021/ja0464802
• 作为产物：
  描述：

  3,4-di(benzyloxy)phenethylamine 在 吡啶 、 4-二甲氨基吡啶 、 N-羟基丁二酰亚胺 、 N,N'-二环己基碳二亚胺 作用下， 以 氯仿 为溶剂， 反应 8.0h， 生成 N-[2-(3,4-bis-benzyloxyphenyl)ethyl]succinimic acid 2,5-dioxo-pyrrolidin-1-yl ester
  参考文献：
  名称：

  Dopamine as A Robust Anchor to Immobilize Functional Molecules on the Iron Oxide Shell of Magnetic Nanoparticles

  摘要：

  We report on the use of dopamine (DA) as a robust molecular anchor to link functional molecules to the iron oxide shell of magnetic nanoparticles. Using nitrilotriacetic acid (NTA) as the functional molecule, we created a system with an M/Fe2O3-DA-NTA (M = Co or SmCo5.2) nanostructure, which possesses high stability and specificity for separating histidine-tagged proteins. The well-established biocompatibility of iron oxide and the robust covalent bonds between DA and Fe2O3 render this strategy attractive for constructing biofunctional magnetic nanoparticles containing iron oxide.

  DOI：

  10.1021/ja0464802

文献信息

• Self-assembled hybrid nanofibers confer a magnetorheological supramolecular hydrogel
  作者：Zhimou Yang、Hongwei Gu、Jun Du、Jinhao Gao、Bei Zhang、Xixiang Zhang、Bing Xu

  DOI：10.1016/j.tet.2007.02.009

  日期：2007.7

  application of a small magnetic field. We use self-assembly to create hybrid nanofibers, which consist of supramolecular hydrogelators and magnetic nanoparticles, as the matrices of the hydrogel. Localized in the nanofibers at a distance of 1–2 nm, the magnetic nanoparticles occupy a small volume fraction of the hydrogel, significantly enhancing the magnetic dipole interactions between them, which

  大多数由液体中的磁性微粒组成的磁流变材料需要大量的磁性微粒和较大的磁场才能达到所需的效果。在这里，我们报告了一种新型的磁流变材料，该材料由少量磁性纳米颗粒（0.8 wt％）组成，但在施加小磁场时表现出较大的流变变化（即，凝胶-溶胶转变）。我们使用自组装来创建杂化纳米纤维，该杂化纳米纤维由超分子水凝胶剂和磁性纳米颗粒组成，作为水凝胶的基质。磁性纳米粒子位于纳米纤维中1-2 nm处，占据了水凝胶的一小部分体积，显着增强了它们之间的磁偶极相互作用，从而导致了较大的磁响应。
• Synthesis and characterization of 5-substituted 8-hydroxyquinoline derivatives and their metal complexes
  作者：Lihua Li、Bing Xu

  DOI：10.1016/j.tet.2008.09.081

  日期：2008.12

  scaffold to generate dimers, trimers, and tetramer metalloquinolates. Starting from QN, a series of 5-substituted 8-hydroxyquinoline derivatives conjugated with small bioactive molecules were synthesized. Absorption and emission spectra indicate that these QN derivatives chelate well with metal ions, which may serve as a new platform to explore the applications of metalloquinolates for a variety of potential

  合成5-氨基甲基-8-羟基喹啉（QN）作为支架，以生成二聚体，三聚体和四聚体金属喹啉酸酯。从QN开始，合成了一系列与小生物活性分子缀合的5-取代的8-羟基喹啉衍生物。吸收和发射光谱表明，这些QN衍生物与金属离子很好地螯合，这可以作为探索金属喹啉酸盐在各种潜在应用中的新平台。
• Synthesis and cellular uptake of porphyrin decorated iron oxide nanoparticles—a potential candidate for bimodal anticancer therapy
  作者：Hongwei Gu、Keming Xu、Zhimou Yang、Chi K. Chang、Bing Xu

  DOI：10.1039/b507779f

  日期：——

  This paper reports the synthesis, characterization, and cellular uptake of the conjugate of porphyrin and iron oxide nanoparticles, which may lead to a bimodal anticancer agent that can be used in the combinational treatment of photodynamic therapy (PDT) and hyperthermia therapy (HT).

  本文报道了卟啉和氧化铁纳米颗粒的共轭物的合成、表征和细胞摄取，这可能会产生一种双峰抗癌剂，可用于光动力疗法（PDT）和热疗（HT）的联合治疗。