2-(bis-carboxymethylamino)-6-{3-[2-(3,4-dihydroxyphenyl)ethylcarbamoyl]propionylamino}hexanoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2-(bis-carboxymethylamino)-6-{3-[2-(3,4-dihydroxyphenyl)ethylcarbamoyl]propionylamino}hexanoic acid
• 英文别名: 2-[Bis(carboxymethyl)amino]-6-[[4-[2-(3,4-dihydroxyphenyl)ethylamino]-4-oxobutanoyl]amino]hexanoic acid；2-[bis(carboxymethyl)amino]-6-[[4-[2-(3,4-dihydroxyphenyl)ethylamino]-4-oxobutanoyl]amino]hexanoic acid
• 化学式: C₂₂H₃₁N₃O₁₀
• 分子量: 497.502
• InChiKey: IPTSIAOZFLCDEJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.4
• 重原子数：
  35
• 可旋转键数：
  17
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  214
• 氢给体数：
  7
• 氢受体数：
  11

反应信息

• 作为产物：
  描述：

  盐酸多巴胺 在 吡啶 、 4-二甲氨基吡啶 、 sodium hydroxide 、 palladium on activated charcoal 、 N-羟基丁二酰亚胺 、 氢气 、 碳酸氢钠 、 potassium carbonate 、 N,N'-二环己基碳二亚胺 、 三氟乙酸 作用下， 以 1,4-二氧六环 、 甲醇 、 乙醇 、 二氯甲烷 、 氯仿 、 N,N-二甲基甲酰胺 为溶剂， 反应 105.17h， 生成 2-(bis-carboxymethylamino)-6-{3-[2-(3,4-dihydroxyphenyl)ethylcarbamoyl]propionylamino}hexanoic acid
  参考文献：
  名称：

  Dopamine as A Robust Anchor to Immobilize Functional Molecules on the Iron Oxide Shell of Magnetic Nanoparticles

  摘要：

  We report on the use of dopamine (DA) as a robust molecular anchor to link functional molecules to the iron oxide shell of magnetic nanoparticles. Using nitrilotriacetic acid (NTA) as the functional molecule, we created a system with an M/Fe2O3-DA-NTA (M = Co or SmCo5.2) nanostructure, which possesses high stability and specificity for separating histidine-tagged proteins. The well-established biocompatibility of iron oxide and the robust covalent bonds between DA and Fe2O3 render this strategy attractive for constructing biofunctional magnetic nanoparticles containing iron oxide.

  DOI：

  10.1021/ja0464802

文献信息

• Dopamine as A Robust Anchor to Immobilize Functional Molecules on the Iron Oxide Shell of Magnetic Nanoparticles
  作者：Chenjie Xu、Keming Xu、Hongwei Gu、Rongkun Zheng、Hui Liu、Xixiang Zhang、Zhihong Guo、Bing Xu

  DOI：10.1021/ja0464802

  日期：2004.8.1

  We report on the use of dopamine (DA) as a robust molecular anchor to link functional molecules to the iron oxide shell of magnetic nanoparticles. Using nitrilotriacetic acid (NTA) as the functional molecule, we created a system with an M/Fe2O3-DA-NTA (M = Co or SmCo5.2) nanostructure, which possesses high stability and specificity for separating histidine-tagged proteins. The well-established biocompatibility of iron oxide and the robust covalent bonds between DA and Fe2O3 render this strategy attractive for constructing biofunctional magnetic nanoparticles containing iron oxide.