bis(N,N-diethylamido)-O-tocopherylphosphite | 562828-32-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: bis(N,N-diethylamido)-O-tocopherylphosphite
• CAS: 562828-32-4
• 化学式: C₃₇H₆₉N₂O₂P
• 分子量: 604.941
• InChiKey: WESFOUURANURQV-GKQJUULYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11.42
• 重原子数：
  42.0
• 可旋转键数：
  20.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.84
• 拓扑面积：
  24.94
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  2,6-双[[3-(叔丁基)-2-羟基-5-甲苯基]甲基]-4-甲基苯酚 、 bis(N,N-diethylamido)-O-tocopherylphosphite 以 甲苯 为溶剂， 反应 24.0h， 生成 8-tert-butyl-6-diethylamino-4-(2-hydroxy-3-tert-butyl-5-methylbenzyl)-2,10-dimethyldibenzo<1,3,2>-dioxaphosphacane
  参考文献：
  名称：

  Cyclophosphorylation of polyphenols by diamidoarylphosphites

  摘要：

  It was found that the cyclophosphorylation of polyphenols by diamidoarylphosphites proceeds via the rupture of only one P-N bond and one P-O bond, the second P-N bond remaining intact, It is supposed that the unusual lack of reactivity of the P-N bond is due to the spatial arrangement of the amido group with respect to the reaction site in phosphorylated intermediates 5. (C) 2003 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(03)00111-x
• 作为产物：
  描述：

  六乙基亚磷酸胺 、 天然维生素E 反应 5.0h， 以100%的产率得到bis(N,N-diethylamido)-O-tocopherylphosphite
  参考文献：
  名称：

  Cyclophosphorylation of polyphenols by diamidoarylphosphites

  摘要：

  It was found that the cyclophosphorylation of polyphenols by diamidoarylphosphites proceeds via the rupture of only one P-N bond and one P-O bond, the second P-N bond remaining intact, It is supposed that the unusual lack of reactivity of the P-N bond is due to the spatial arrangement of the amido group with respect to the reaction site in phosphorylated intermediates 5. (C) 2003 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(03)00111-x