| 916483-31-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 916483-31-3
• 化学式: C₃₉H₇₀N₂O₁₃
• 分子量: 774.99
• InChiKey: OASHHOWHMGPUIJ-IRNFSOKPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.86
• 重原子数：
  54.0
• 可旋转键数：
  9.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  220.86
• 氢给体数：
  6.0
• 氢受体数：
  15.0

反应信息

• 作为反应物：
  描述：

  在 palladium on activated charcoal 盐酸 、 氢气 、 溶剂黄146 、 tetramethylammonium triacetoxyborohydride 作用下， 以 甲醇 、 1,2-二氯乙烷 为溶剂， 生成
  参考文献：
  名称：

  Design, synthesis and in vivo activity of 9-(S)-dihydroerythromycin derivatives as potent anti-inflammatory agents

  摘要：

  The synthesis of a new class of 9-(S)-dihydroerythromycin derivatives and their anti-inflammatory activity on in vivo PMA assay are described. Modifying the desosamine sugar on the C-3' amino group, it was possible to differentiate between anti-biotic and anti-flammatory action. The compounds are completely devoid of anti-microbial effects but their anti-inflammatory properties are enhanced. These results strongly suggest the potential of macrolides as a new class of anti-inflammatory agents. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.08.076
• 作为产物：
  描述：

  (9S)-9-dihydroerythromycin A 在 偶氮二甲酸二乙酯 作用下， 以 二氯甲烷 为溶剂， 反应 22.0h， 生成
  参考文献：
  名称：

  Design, synthesis and in vivo activity of 9-(S)-dihydroerythromycin derivatives as potent anti-inflammatory agents

  摘要：

  The synthesis of a new class of 9-(S)-dihydroerythromycin derivatives and their anti-inflammatory activity on in vivo PMA assay are described. Modifying the desosamine sugar on the C-3' amino group, it was possible to differentiate between anti-biotic and anti-flammatory action. The compounds are completely devoid of anti-microbial effects but their anti-inflammatory properties are enhanced. These results strongly suggest the potential of macrolides as a new class of anti-inflammatory agents. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.08.076

文献信息

• [EN] MACROLIDE COMPOUNDS ENDOWED WITH ANTIINFLAMMATORY ACTIVITY<br/>[FR] COMPOSES DE MACROLIDES AYANT UNE ACTIVITE ANTI-INFLAMMATOIRE
  申请人：ZAMBON SPA

  公开号：WO2004013153A3

  公开（公告）日：2004-04-08