2-[(2S)-oxiran-2-yl]-2-oxoacetaldehyde | 294212-37-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-[(2S)-oxiran-2-yl]-2-oxoacetaldehyde
• CAS: 294212-37-6
• 化学式: C₄H₄O₃
• 分子量: 100.074
• InChiKey: MLGBZDDVWCNOKO-BYPYZUCNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  7
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  46.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  美司坦 、 2-[(2S)-oxiran-2-yl]-2-oxoacetaldehyde 在 potassium hydrogencarbonate 作用下， 以 乙醇 为溶剂， 生成
  参考文献：
  名称：

  Nonracemic 2-Diazo-1-oxiranyl-ethanone, a Versatile Chiral Epoxide Educt in Diazocarbonyl Reactions

  摘要：

  [GRAPHICS](S)-(-)-2-Diazo-1-oxiranyl-ethanone, prepared in two steps from (R)-(+)-glycidol, has been employed as an intermediate in several characteristic diazocarbonyl reactions to yield novel, nonracemic products including an epoxy quinoxaline and epoxy thiazoles and oxazoles.

  DOI：

  10.1021/ol000034b
• 作为产物：
  描述：

  (S)-(-)-2-diazo-1-oxyranyl-ethanone 在 二甲基二环氧乙烷 作用下， 以 丙酮 为溶剂， 以100%的产率得到2-[(2S)-oxiran-2-yl]-2-oxoacetaldehyde
  参考文献：
  名称：

  Nonracemic 2-Diazo-1-oxiranyl-ethanone, a Versatile Chiral Epoxide Educt in Diazocarbonyl Reactions

  摘要：

  [GRAPHICS](S)-(-)-2-Diazo-1-oxiranyl-ethanone, prepared in two steps from (R)-(+)-glycidol, has been employed as an intermediate in several characteristic diazocarbonyl reactions to yield novel, nonracemic products including an epoxy quinoxaline and epoxy thiazoles and oxazoles.

  DOI：

  10.1021/ol000034b

文献信息

• Nonracemic 2-Diazo-1-oxiranyl-ethanone, a Versatile Chiral Epoxide Educt in Diazocarbonyl Reactions
  作者：Michelle Groarke、M. Anthony McKervey、Hugues Miel、Mark Nieuwenhuyzen

  DOI：10.1021/ol000034b

  日期：2000.8.1

  [GRAPHICS](S)-(-)-2-Diazo-1-oxiranyl-ethanone, prepared in two steps from (R)-(+)-glycidol, has been employed as an intermediate in several characteristic diazocarbonyl reactions to yield novel, nonracemic products including an epoxy quinoxaline and epoxy thiazoles and oxazoles.